Figure 3From: There is a specific response to pH by isolates of Haemophilus influenzae and this has a direct influence on biofilm formation The pathway uniquely induced in H. influenzae Eagan at pHÂ 8.0. (A) Genes HI1010-1015 (block arrows, grey) were all induced in H. influenzae Eagan at pHÂ 8.0. In silico analysis identified 2 promoters across this region of the genome (indicated by line arrows) and HI1010-HI1015 forms a single operon. (B) These HI1010-1015 genes encode a gluconate:H+ symporter, a putative 6-phospohogluconate dehydrogenase and a range of sugar isomerases and epimerases that would link gluconate to the PPP and other metabolic pathways (the putative role for these genes are shown in blue).Back to article page