TY - JOUR AU - Song, Ke-Yu AU - Zhao, Hui AU - Jiang, Zhen-You AU - Li, Xiao-Feng AU - Deng, Yong-Qiang AU - Jiang, Tao AU - Zhu, Shun-Ya AU - Shi, Pei-Yong AU - Zhang, Bo AU - Zhang, Fu-Chun AU - Qin, E-De AU - Qin, Cheng-Feng PY - 2014 DA - 2014/02/18 TI - A novel reporter system for neutralizing and enhancing antibody assay against dengue virus JO - BMC Microbiology SP - 44 VL - 14 IS - 1 AB - Dengue virus (DENV) still poses a global public health threat, and no vaccine or antiviral therapy is currently available. Antibody plays distinct roles in controlling DENV infections. Neutralizing antibody is protective against DENV infection, whereas sub-neutralizing concentration of antibody can increase DENV infection, termed antibody-dependent enhancement (ADE). Plaque-based assay represents the most widely accepted method measuring neutralizing or enhancing antibodies. SN - 1471-2180 UR - https://doi.org/10.1186/1471-2180-14-44 DO - 10.1186/1471-2180-14-44 ID - Song2014 ER -