The Vibrio cholerae diguanylate cyclase VCA0965 has an AGDEF active site and synthesizes cyclic di-GMP

BMC Microbiology

Table 2 Bioinformatic analysis of the frequency of the AG(D/E)EF active site motif

	Number of proteins	Percentage of total GGDEFs	Percentage of total AG(D/E)EF proteins
Total GGDEF domain containing proteins analyzed	28,254	100	n/a
Proteins containing an AG(D/E)EF motif	440	1.56	100
Proteins containing an AG(D/E)EF motif and an RXXD motif	205	0.73	46.59
Proteins containing an AG(D/E)EF motif from Vibrio sp.	100	0.35	22.73
Known GGDEF domain containing proteins from Vibrio sp.	2946	10.43	n/a
Proteins containing an RXXD and an XG(D/E)EF motif	12410	43.92	n/a

ISSN: 1471-2180