Biofilms formed by Candida albicans bloodstream isolates display phenotypic and transcriptional heterogeneity that are associated with resistance and pathogenicity

Leighann Sherry; Ranjith Rajendran; David F Lappin; Elisa Borghi; Federica Perdoni; Monica Falleni; Delfina Tosi; Karen Smith; Craig Williams; Brian Jones; Chris J Nile; Gordon Ramage

doi:10.1186/1471-2180-14-182

Table 2 C albicans biomass correlates with biofilm-related gene expression

From: Biofilms formed by Candida albicans bloodstream isolates display phenotypic and transcriptional heterogeneity that are associated with resistance and pathogenicity

4 h Correlations^a		ALS3	EAP1	CPH1	SAP5	PLB1	CDR1	ZAP1
CV	Rho=	.529 ^*	.608 ^**	.534 ^*	.539 ^*	.483 ^*	.647 ^**	.515 ^*
	p =	.029	.010	.027	.026	.050	.005	.035
ALS1	Rho=	.240	.529 ^*	.542 ^*	.336	.608 ^**	.382	.250
	p =	.353	.029	.025	.188	.010	.130	.333
ALS3	Rho=	1.000	.385	.708 ^**	.544 ^*	.593 ^*	.779 ^**	.365
	p =		.127	.001	.024	.012	.000	.149
ALS5	Rho=	.229	.538 ^*	.644 ^**	.607 ^**	.681 ^**	.145	.214
	p =	.378	.026	.005	.010	.003	.579	.410
EAP1	Rho=	.385	1.000	.544 ^*	.490 ^*	.860 ^**	.537 ^*	.279
	p =	.127		.024	.046	.000	.026	.277
HWP1	Rho=	.868 ^**	.338	.821 ^**	.571 ^*	.532 ^*	.615 ^**	.201
	p =	.000	.184	.000	.017	.028	.009	.439
MNN4	Rho=	.350	.554 ^*	.645 ^**	.537 ^*	.672 ^**	.493 ^*	.309
	p =	.168	.021	.005	.026	.003	.045	.228
PMR1	Rho=	.333	.635 ^**	.527 ^*	.534 ^*	.784 ^**	.233	.377
	p =	.191	.006	.030	.027	.000	.368	.135
BCR1	Rho=	.262	.250	.539 ^*	.566 ^*	.485 ^*	.306	.522 ^*
	p =	.309	.333	.026	.018	.048	.232	.032
CPH1	Rho=	.708 ^**	.544 ^*	1.000	.833 ^**	.748 ^**	.547 ^*	.321
	p =	.001	.024		.000	.001	.023	.209
EFG1	Rho=	.257	.520 ^*	.576 ^*	.645 ^**	.605 ^*	.409	.392
	p =	.319	.033	.016	.005	.010	.103	.119
TUP1	Rho=	.713 ^**	.397	.397	.463	.544 ^*	.684 ^**	.444
	p =	.001	.115	.115	.061	.024	.002	.074
SAP1	Rho=	.356	.523 ^*	.794 ^**	.744 ^**	.730 ^**	.251	.413
	p =	.160	.031	.000	.001	.001	.332	.100
SAP2	Rho=	.091	.554 ^*	.478	.417	.654 ^**	.172	.292
	p =	.729	.021	.052	.096	.004	.510	.256
SAP5	Rho=	.544 ^*	.490^*	.833^**	1.000	.676 ^**	.395	.539 ^*
	p =	.024	.046	.000		.003	.117	.026
SAP6	Rho=	.371	.772 ^**	.637 ^**	.627 ^**	.869 ^**	.320	.284
	p =	.143	.000	.006	.007	.000	.211	.269
PLB1	Rho=	.593 ^*	.860 ^**	.748 ^**	.676 ^**	1.000	.532 ^*	.434
	p =	.012	.000	.001	.003		.028	.082
CDR1	Rho=	.779 ^**	.537 ^*	.547 ^*	.395	.532 ^*	1.000	.262
	p =	.000	.026	.023	.117	.028		.309
ZAP1	Rho=	.365	.279	.321	.539 ^*	.434	.262	1.000
	p =	.149	.277	.209	.026	.082	.309

*Correlation is significant at the 0.05 level (2-tailed), ** Correlation is significant at the 0.01 level (2-tailed).
a. List wise N = 17.

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