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Table 2 S. pneumoniae gene expression in the presence of norepinephrine

From: Host stress hormone norepinephrine stimulates pneumococcal growth, biofilm formation and virulence gene expression

Transcriptional regulators Function Fold change in expression
D39 pspA - pspC -
comX (SPD_0014) Transcriptional regulator ComX1 5.33 (0.15) 0.85 (0.03) 0.92 (0.09)
rgg (SPD_0144) Transcriptional regulator 1.72 (0.12) 0.40 (0.06) 1.13 (0.15)
ritR (SPD_0344) DNA-binding response regulator 0.77 (0.04) 0.73 (0.02) 0.97 (0.04)
rgg / mutR (SPD_0939) Transcriptional regulator 28.4 (2.2) 0.79 (0.06) 1.09 (0.13)
Sugar hydrolases
strH (SPD_0063) N-acetyl hexosaminidase 6.56 (0.30) 0.6 (0.02) 0.97 (0.04)
bga3 (SPD_0065) β-galactosidase 21.4 (2.0) 0.78 (0.04) 1.1 (0.05)
nanB (SPD_1499) Neuraminidase B 22.39 (1.10) 1.23 (0.12) 0.78 (0.08)
nanA (SPD_1504) Neuraminidase A 10.77 (0.89) 1.44 (0.07) 0.98 (0.04)
Cation metabolism
piuA (SPD_1652) Iron-compound ABC transporter 6.08 (0.20) 0.27 (0.03) 1.02 (0.03)
psaA (SPD_1463) ABC transporter substrate-binding protein 1.22 (0.04) 0.48 (0.03) 1.04 (0.03)
Sugar metabolism
pflB (SPD_0420) Pyruvate formate lyase 0.59 (0.03) 0.89 (0.02) 1.03 (0.06)
spxB (SPD_0722) Pyruvate oxidase 0.16 (0.07) 0.69 (0.03) 0.84 (0.12)
galK (SPD_1634) Galactokinase 25.36 (2.39) 0.78 (0.04) 0.92 (0.07)
Oxidative stress response
tpxD (SPD_1464) Thiolperoxidase 0.66 (0.07) 0.74 (0.06) 0.81 (0.1)
  1. The relative gene expression levels of wildtype D39 and the pspA and pspC mutants was calculated from 3 independent experiments and standard deviation is indicated in parenthesis. The expression of target genes was normalised to the housekeeping gene gyrB.