Table 2 S. pneumoniae gene expression in the presence of norepinephrine
Transcriptional regulators | Function | Fold change in expression | ||
|---|---|---|---|---|
D39 | pspA - | pspC - | ||
comX (SPD_0014) | Transcriptional regulator ComX1 | 5.33 (0.15) | 0.85 (0.03) | 0.92 (0.09) |
rgg (SPD_0144) | Transcriptional regulator | 1.72 (0.12) | 0.40 (0.06) | 1.13 (0.15) |
ritR (SPD_0344) | DNA-binding response regulator | 0.77 (0.04) | 0.73 (0.02) | 0.97 (0.04) |
rgg / mutR (SPD_0939) | Transcriptional regulator | 28.4 (2.2) | 0.79 (0.06) | 1.09 (0.13) |
Sugar hydrolases | ||||
strH (SPD_0063) | N-acetyl hexosaminidase | 6.56 (0.30) | 0.6 (0.02) | 0.97 (0.04) |
bga3 (SPD_0065) | β-galactosidase | 21.4 (2.0) | 0.78 (0.04) | 1.1 (0.05) |
nanB (SPD_1499) | Neuraminidase B | 22.39 (1.10) | 1.23 (0.12) | 0.78 (0.08) |
nanA (SPD_1504) | Neuraminidase A | 10.77 (0.89) | 1.44 (0.07) | 0.98 (0.04) |
Cation metabolism | ||||
piuA (SPD_1652) | Iron-compound ABC transporter | 6.08 (0.20) | 0.27 (0.03) | 1.02 (0.03) |
psaA (SPD_1463) | ABC transporter substrate-binding protein | 1.22 (0.04) | 0.48 (0.03) | 1.04 (0.03) |
Sugar metabolism | ||||
pflB (SPD_0420) | Pyruvate formate lyase | 0.59 (0.03) | 0.89 (0.02) | 1.03 (0.06) |
spxB (SPD_0722) | Pyruvate oxidase | 0.16 (0.07) | 0.69 (0.03) | 0.84 (0.12) |
galK (SPD_1634) | Galactokinase | 25.36 (2.39) | 0.78 (0.04) | 0.92 (0.07) |
Oxidative stress response | ||||
tpxD (SPD_1464) | Thiolperoxidase | 0.66 (0.07) | 0.74 (0.06) | 0.81 (0.1) |