TY - JOUR AU - Yin, Huaqun AU - Zhang, Xian AU - Li, Xiaoqi AU - He, Zhili AU - Liang, Yili AU - Guo, Xue AU - Hu, Qi AU - Xiao, Yunhua AU - Cong, Jing AU - Ma, Liyuan AU - Niu, Jiaojiao AU - Liu, Xueduan PY - 2014 DA - 2014/07/04 TI - Whole-genome sequencing reveals novel insights into sulfur oxidation in the extremophile Acidithiobacillus thiooxidans JO - BMC Microbiology SP - 179 VL - 14 IS - 1 AB - Acidithiobacillus thiooxidans (A. thiooxidans), a chemolithoautotrophic extremophile, is widely used in the industrial recovery of copper (bioleaching or biomining). The organism grows and survives by autotrophically utilizing energy derived from the oxidation of elemental sulfur and reduced inorganic sulfur compounds (RISCs). However, the lack of genetic manipulation systems has restricted our exploration of its physiology. With the development of high-throughput sequencing technology, the whole genome sequence analysis of A. thiooxidans has allowed preliminary models to be built for genes/enzymes involved in key energy pathways like sulfur oxidation. SN - 1471-2180 UR - https://doi.org/10.1186/1471-2180-14-179 DO - 10.1186/1471-2180-14-179 ID - Yin2014 ER -