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Table 2 Viral parameters for correlation tests with coagulation results from 0.5-4 dpi

From: Activation of coagulation and tissue fibrin deposition in experimental influenza in ferrets

Virus

Day

Virus titer*

Lung virus AUC#

Respiratory tract AUC#

H3N2

0.5

3.5 (2.9-4.2)

neg

0

1

7.0 (5.5-8.5)

neg

2.6

2

6.3 (5.4-7.3)

neg

9.3

3

5.1 (3.9-6.2)

neg

15

4

4.8 (3.4-6.1)

neg

19.9

pH1N1

0.5

26.0 (24.3-27.7)

0

0

1

31.7 (31.1-32.3)

3.6

14.4

2

27.0 (26.4-27.6)

10.0

43.8

3

27.0 (25.7-28.4)

15.4

70.8

4

25.7 (23.4-28.0)

20.1

97.1

H5N1

0.5

22.3 (19.5-25.2)

0

0

1

27.61 (24.4-30.8)

3.1

12.5

2

24.8 (22.3-27.3)

9.0

38.7

3

26.1 (22.0-30.8)

14.5

64.3

4

26.0 (23.9-28.0)

19.9

90.5

  1. *Total virus titer in log TCID50 (cumulative titers of all organs with significant virus titers: “lung, nasal concha, trachea, bronchus and bronchial lymph nodes”) (+/- SD).
  2. # AUC was calculated from virus titers curves. 7 dpi and 14 dpi were excluded from the analysis because we data points from 5 & 6 dpi are not available potentially resulting in over or underestimation of the true AUC.