Genotype designationsa
|
PBP3 substitutionsb
|
---|
SSN
|
KTG
|
---|
Categoryc
|
Level
|
Group
|
S385
|
R517
|
N526
|
---|
rPBP3
|
High
|
IIId
|
T
| |
K
|
| |
III-likee
|
T
|
H
| |
|
Low
|
II
| | |
K
|
| |
I
| |
H
| |
sPBP3
|
NA
|
NA
| | | |
-
aAccording to Ubukata et al.[7], Hasegawa et al.[8], Garcia-Cobos et al.[9], Hotomi et al.[10] and this study. NA, not applicable.
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bEssential amino acid substitutions in PBP3 (transpeptidase domain, 338–573) with the amino acid sequence of H. influenzae Rd KW20 [GenBank:U32793] as reference. SSN, Ser-Ser-Asn motif; KTG, Lys-Thr-Gly motif.
-
crPBP3, isolates with PBP3 sequences conferring resistance to beta-lactams (isolates assigned to groups I, II, III-like and III); sPBP3, isolates with PBP3 sequences conferring wild-type susceptibility to beta-lactams (remaining isolates).
-
dOriginally reserved for isolates with the additional substitutions M377I and L389F by Ubukata et al.[7], modification proposed by Hotomi et al.[10].
-
eOriginally categorized as group I by Ubukata et al.[7], new group assignment proposed by Garcia-Cobos et al.[9].