Drug | MIC (μg/ml)a | ||||
---|---|---|---|---|---|
 | Ea1189 | Ea1189.acrD | Ea1189-3 (pBlueSK.acrD) | Ea1189-3 (pBlueKS.acrD) | Ea1189-3 (pBlueKS.acrD-ext) |
 |  |  | Plac < < acrD | Plac> > acrD | Plac, PacrD> > acrD |
Antimicrobials | Â | Â | Â | Â | Â |
Benzalkonium chloride | 12.5 | 12.5 | 1.2 | 1.2 | ND |
Chloramphenicol | 3.1 | ND | 1.2 | 1.2 | 1.2 |
Clotrimazole | > 1000 | > 1000 | 6.2 | 12.5 | 25 |
Fusaric acid | 500 | 500 | 500 | 500 | 500 |
Fusidic acid | 250 | 250 | 3.1 | 6.2 | 25 |
Genistein | > 5000 | > 5000 | 62.5 | 62.5 | 62.5 |
Josamycin | 125 | 125 | 3.1 | 3.1 | 3.1 |
Luteolin | > 5000 | > 5000 | 15.63 | 15.6 | 125 |
Naladixic acid | 2.5 | 2.5 | 1.2 | 1.2 | 1.2 |
Naringenin | 5000 | 5000 | 312 | 312 | 312 |
Nitrofurantoin | 25 | 12.5 | 12.5 | 12.5 | 12.5 |
Norfloxacin | 0.63 | 0.63 | 0.03 | 0.03 | 0.03 |
Novobiocin | 250 | 250 | 6.2 | 25 | 100 |
Phloretin | 5000 | 5000 | 625 | 625 | 625 |
Rifampicin | 12.5 | 12.5 | 12.5 | 12.5 | 12.5 |
Tetracycline | 1.5 | 1.5 | 1.2 | 1.2 | 1.2 |
Aminoglycosides | Â | Â | Â | Â | Â |
Amikacin | 2.5 | 2.5 | 2.5 | 2.5 | 2.5 |
Gentamicin | 2.5 | 2.5 | 2.5 | 2.5 | 2.5 |
Hygromycin B | 100 | 100 | 62.5 | 125 | 125 |
Streptomycin | 2.5 | 2.5 | 2.5 | 2.5 | 2.5 |
Tobramycin | 2.5 | 2.5 | 2.5 | 2.5 | 2.5 |
Macrolids | Â | Â | Â | Â | Â |
Azithromycin | 0.31 | 0.31 | 0.63 | 0.63 | 0.63 |
Clarithromycin | 0.31 | 0.31 | 0.31 | 0.31 | 0.31 |
Erythromycin | 0.63 | 0.31 | 0.16 | 0.16 | 0.16 |
Roxithromycin | 1.25 | 1.25 | 0.16 | 0.16 | 0.16 |
Heavy metals | Â | Â | Â | Â | Â |
Cadmium acetate | 12.5 | 12.5 | 25 | 50 | 50 |
Cobalt (II) chloride | 625 | 625 | 1250 | 1250 | 1250 |
Copper (II) sulfate | 1250 | 1250 | 1250 | 1250 | 1250 |
Nickel (II) chloride | 1250 | 1250 | 2500 | 2500 | 2500 |
Silver nitrate | 12.5 | 6.2 | 6.2 | 6.2 | 6.2 |
Sodium tungstate | 125000 | 62500 | 125000 | 125000 | 125000 |
Zinc sulfate | 156 | 156 | 156 | 312 | 312 |
Dyes | Â | Â | Â | Â | Â |
Acriflavine | 50 | 50 | 6.2 | 6.2 | 6.2 |
Crystal violet | 3.1 | 3.1 | 2.5 | 2.5 | 2.5 |
Ethidium bromide | 250 | 250 | 3.1 | 3.1 | 6.2 |
Rhodamine 6G | > 100 | > 100 | 3.1 | 3.1 | 3.1 |
Detergents | Â | Â | Â | Â | Â |
Bile salt | 5000 | 5000 | 625 | 1250 | 5000 |
Deoxycholate | > 1000 | > 1000 | 312 | 1250 | 2500 |
SDS | > 1000 | > 1000 | 62.5 | 125 | 125 |