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Table 1 Interaction of fosfomycin and clarithromycin against MRSP biofilms by microdilution arrays

From: In vitro synergism of fosfomycin and clarithromycin antimicrobials against methicillin-resistant Staphylococcus pseudintermedius

Isolate selected

Sequence type

Dru type

Adherence capabilities

FOS (μg/ml) MIC

CLA (μg/ml) MIC

FICI

A12

68

10h

STRONG

≥1

≥256

NA

A46

71

9a

MODERATE

≥64

≥256

0.31

A56

71

9a

LOW

≥32

≥256

0.56

A92

71

9a

MODERATE

≥64

≥256

0.31

SP90

71

9a

STRONG

≥32

≥256

0.56

SP106

71

9a

LOW

≥64

≥256

0.31

SP112

71

9a

LOW

≥64

≥256

0.31

SP113

71

9a

LOW

≥64

≥256

0.31

  1. Adherence capabilities were determined based on the model developed by Stepanovic et al., 2000. Fosfomycin and Clarithromycin susceptibility was determined by agar dilution and Kirby Bauer disk diffusion, respectively.