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Table 2 Predicted topologies for members of the 34 families of uptake porters in the ABC superfamily (TC# 3.A.1) 1

From: Evolutionary relationships of ATP-Binding Cassette (ABC) uptake porters

  Family name No. of membrane proteins in TCDB No. of membrane proteins/system Average predicted #TMSs No. of predicted TMSs for family members. The “*” indicates the most abundant topological type Predicted number of TMS (# of such proteins is shown in parentheses)
1 The Carbohydrate Uptake Transporter-1 (CUT1) Family 35 2 6.6 ± 1.1 6*,7, 8 6 (16), 7 (8), 8 (10)
2 The Carbohydrate Uptake Transporter-2 (CUT2) Family 17 1 or 2 9.4 ± 1.1 7, 8, 9, 10*, 12 7 (1), 8 (2), 9 (5), 10 (8), 12 (1)
3 The Polar Amino Acid Uptake Transporter (PAAT) Family 21 2 or 1 5.9 ± 1.8 5*, 6, 8, 9, 10, 11 5 (15), 6 (2), 9 (1), 10 (1), 11 (1)
4 The Hydrophobic Amino Acid Uptake Transporter (HAAT) Family 6 2 9.8 ± 0.7 9, 10*, 11 9 (2), 10 (3), 11 (1)
5 The Peptide/Opine/Nickel Uptake Transporter (PepT) Family 27 2 6.2 ± 1.2 5, 6*, 7, 8 6 (19), 7 (3), 8 (2)
6 The Sulfate/Tungstate Uptake Transporter (SulT) Family 7 1 or 2 5.7 ± 0.5 5, 6* 5 (2), 6 (5)
7 The Phosphate Uptake Transporter (PhoT) Family 2 2 6.5 ± 0.5 6*, 7 6 (1), 7 (1)
8 The Molybdate Uptake Transporter (MolT) Family 2 1 5.0 ± 0 5 5 (2)
9 The Phosphonate Uptake Transporter (PhnT) Family 2 1 9.0 ± 3.0 6*, 12* 6 (1), 12 (1)
10 The Ferric Iron Uptake Transporter (FeT) Family 4 1 11.8 ± 0.4 12 11 (1), 12 (3)
11 The Polyamine/Opine/Phosphonate Uptake Transporter (POPT) Family 6 2 6.0 ± 0 6 6 (6)
12 The Quaternary Amine Uptake Transporter (QAT) Family 13 1 or 2 6.4 ± 1.3 5*, 6, 7, 8, 9 5 (4), 6 (4), 7 (2), 8 (2), 9 (1)
13 The Vitamin B12 Uptake Transporter (B12T) Family 1 1 9.0 ± 0 9* 9 (1)
14 The Iron Chelate Uptake Transporter (FeCT) Family 27 2 or 1 9.6 ± 3.9 7, 8, 9*, 10, 11, 20 7 (3), 8 (1), 9 (10), 10 (4), 11 (1), 20 (2)
15 The Manganese/Zinc/Iron Chelate Uptake Transporter (MZT) Family 11 1 or 2 8.0 ± 0.9 7, 8*, 9 7 (4), 8 (3), 9 (4)
16 The Nitrate/Nitrite/Cyanate Uptake Transporter (NitT) Family 3 1 6.0 ± 0 6 6 (3)
17 The Taurine Uptake Transporter (TauT) Family 6 1 6.0 ± 0 6 6 (6)
18 The Cobalt Uptake Transporter (CoT) Family 1 2 (ECF) 6.0 ± 0 5*, 6* 6 (1)
19 The Thiamin Uptake Transporter (ThiT) Family 2 1 12.0 ± 0 12* 12 (2)
20 The Brachyspira Iron Transporter (BIT) Family 1 2 7.0 ± 0 6, 7 7 (1)
21 (ABC1) The Siderophore-Fe3+ Uptake Transporter (SIUT) Family 2 2 (ECF) 6.5 ± 0.5 6, 7 6 (1), 7 (1)
22 The Nickel Uptake Transporter (NiT) Family 1 2 (ECF) 5.0 ± 0 5 5 (1)
23 The Nickel/Cobalt Uptake Transporter (NiCoT) Family 2 2 (ECF) 1.5 ± 0.5 5, 6*, 7 6 (1), 7 (1)
24 The Methionine Uptake Transporter (MUT) Family 4 1 5.0 ± 0 5 5 (4)
25 The Biotin Uptake Transporter (BioMNY) Family 1 2 (ECF) 5.0 ± 0 5* 5 (1)
26 The Putative Thiamine Uptake Transporter (ThiW) Family 7 2 (ECF) 5.6 ± 0.7 5 5 (4), 6 (2), 7 (1),
27 The γ-Hexachlorocyclohexane (HCH) Family 5 1 5.4 ± 0.5 5*, 6 5 (3), 6 (2)
28 The Queusine (Quesusine) Family 2 2 (ECF) 5.5 ± 0.5 5, 6 5 (1), 6 (1)
29 The Methionine precursor (Met-P) Family 2 2 (ECF) 5.5 ± 0.5 5, 6 5 (1), 6 (1)
30 The Thiamin precursor (Thi-P) Family 2 2 (ECF) 6.0 ± 0 4, 6 6 (2)
31 The Unknown-ABC1 (U-ABC1) Family 2 2 (ECF) 6.0 ± 0 6 6 (2)
32 The Cobalamine Precursor (B12-P) Family 2 2 (ECF) 8.0 ± 0 6, 8 6 (1), 8 (1)
33 The Methylthioadenosine (MTA) Family 2 2 6.5 ± 0 6, 7 6 (1), 7 (1)
34 The Tryptophan (TrpXYZ) Family 1 1 8.0 ± 0 8 8 (1)
35 The Cobalamin precursor/Cobalt (CPC) Family 2 2 5.7 ± 1 6 4 (2) 6 (2) 7 (2)
  1. 1 Most uptake porters are of the ABC2 type. However, TC# 3.A.1.21 porters belong to the ABC1 type. Blasting family 21 porters yielded ABC1 exporters in families TC# 3.A.1.101 to TC# 3.A.1.113 [9].
  2. Proteins were derived from TCDB.
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