Table 2 Predicted topologies for members of the 34 families of uptake porters in the ABC superfamily (TC# 3.A.1) 1
From: Evolutionary relationships of ATP-Binding Cassette (ABC) uptake porters
Family name | No. of membrane proteins in TCDB | No. of membrane proteins/system | Average predicted #TMSs | No. of predicted TMSs for family members. The “*” indicates the most abundant topological type | Predicted number of TMS (# of such proteins is shown in parentheses) | |
|---|---|---|---|---|---|---|
1 | The Carbohydrate Uptake Transporter-1 (CUT1) Family | 35 | 2 | 6.6 ± 1.1 | 6*,7, 8 | 6 (16), 7 (8), 8 (10) |
2 | The Carbohydrate Uptake Transporter-2 (CUT2) Family | 17 | 1 or 2 | 9.4 ± 1.1 | 7, 8, 9, 10*, 12 | 7 (1), 8 (2), 9 (5), 10 (8), 12 (1) |
3 | The Polar Amino Acid Uptake Transporter (PAAT) Family | 21 | 2 or 1 | 5.9 ± 1.8 | 5*, 6, 8, 9, 10, 11 | 5 (15), 6 (2), 9 (1), 10 (1), 11 (1) |
4 | The Hydrophobic Amino Acid Uptake Transporter (HAAT) Family | 6 | 2 | 9.8 ± 0.7 | 9, 10*, 11 | 9 (2), 10 (3), 11 (1) |
5 | The Peptide/Opine/Nickel Uptake Transporter (PepT) Family | 27 | 2 | 6.2 ± 1.2 | 5, 6*, 7, 8 | 6 (19), 7 (3), 8 (2) |
6 | The Sulfate/Tungstate Uptake Transporter (SulT) Family | 7 | 1 or 2 | 5.7 ± 0.5 | 5, 6* | 5 (2), 6 (5) |
7 | The Phosphate Uptake Transporter (PhoT) Family | 2 | 2 | 6.5 ± 0.5 | 6*, 7 | 6 (1), 7 (1) |
8 | The Molybdate Uptake Transporter (MolT) Family | 2 | 1 | 5.0 ± 0 | 5 | 5 (2) |
9 | The Phosphonate Uptake Transporter (PhnT) Family | 2 | 1 | 9.0 ± 3.0 | 6*, 12* | 6 (1), 12 (1) |
10 | The Ferric Iron Uptake Transporter (FeT) Family | 4 | 1 | 11.8 ± 0.4 | 12 | 11 (1), 12 (3) |
11 | The Polyamine/Opine/Phosphonate Uptake Transporter (POPT) Family | 6 | 2 | 6.0 ± 0 | 6 | 6 (6) |
12 | The Quaternary Amine Uptake Transporter (QAT) Family | 13 | 1 or 2 | 6.4 ± 1.3 | 5*, 6, 7, 8, 9 | 5 (4), 6 (4), 7 (2), 8 (2), 9 (1) |
13 | The Vitamin B12 Uptake Transporter (B12T) Family | 1 | 1 | 9.0 ± 0 | 9* | 9 (1) |
14 | The Iron Chelate Uptake Transporter (FeCT) Family | 27 | 2 or 1 | 9.6 ± 3.9 | 7, 8, 9*, 10, 11, 20 | 7 (3), 8 (1), 9 (10), 10 (4), 11 (1), 20 (2) |
15 | The Manganese/Zinc/Iron Chelate Uptake Transporter (MZT) Family | 11 | 1 or 2 | 8.0 ± 0.9 | 7, 8*, 9 | 7 (4), 8 (3), 9 (4) |
16 | The Nitrate/Nitrite/Cyanate Uptake Transporter (NitT) Family | 3 | 1 | 6.0 ± 0 | 6 | 6 (3) |
17 | The Taurine Uptake Transporter (TauT) Family | 6 | 1 | 6.0 ± 0 | 6 | 6 (6) |
18 | The Cobalt Uptake Transporter (CoT) Family | 1 | 2 (ECF) | 6.0 ± 0 | 5*, 6* | 6 (1) |
19 | The Thiamin Uptake Transporter (ThiT) Family | 2 | 1 | 12.0 ± 0 | 12* | 12 (2) |
20 | The Brachyspira Iron Transporter (BIT) Family | 1 | 2 | 7.0 ± 0 | 6, 7 | 7 (1) |
21 (ABC1) | The Siderophore-Fe3+ Uptake Transporter (SIUT) Family | 2 | 2 (ECF) | 6.5 ± 0.5 | 6, 7 | 6 (1), 7 (1) |
22 | The Nickel Uptake Transporter (NiT) Family | 1 | 2 (ECF) | 5.0 ± 0 | 5 | 5 (1) |
23 | The Nickel/Cobalt Uptake Transporter (NiCoT) Family | 2 | 2 (ECF) | 1.5 ± 0.5 | 5, 6*, 7 | 6 (1), 7 (1) |
24 | The Methionine Uptake Transporter (MUT) Family | 4 | 1 | 5.0 ± 0 | 5 | 5 (4) |
25 | The Biotin Uptake Transporter (BioMNY) Family | 1 | 2 (ECF) | 5.0 ± 0 | 5* | 5 (1) |
26 | The Putative Thiamine Uptake Transporter (ThiW) Family | 7 | 2 (ECF) | 5.6 ± 0.7 | 5 | 5 (4), 6 (2), 7 (1), |
27 | The γ-Hexachlorocyclohexane (HCH) Family | 5 | 1 | 5.4 ± 0.5 | 5*, 6 | 5 (3), 6 (2) |
28 | The Queusine (Quesusine) Family | 2 | 2 (ECF) | 5.5 ± 0.5 | 5, 6 | 5 (1), 6 (1) |
29 | The Methionine precursor (Met-P) Family | 2 | 2 (ECF) | 5.5 ± 0.5 | 5, 6 | 5 (1), 6 (1) |
30 | The Thiamin precursor (Thi-P) Family | 2 | 2 (ECF) | 6.0 ± 0 | 4, 6 | 6 (2) |
31 | The Unknown-ABC1 (U-ABC1) Family | 2 | 2 (ECF) | 6.0 ± 0 | 6 | 6 (2) |
32 | The Cobalamine Precursor (B12-P) Family | 2 | 2 (ECF) | 8.0 ± 0 | 6, 8 | 6 (1), 8 (1) |
33 | The Methylthioadenosine (MTA) Family | 2 | 2 | 6.5 ± 0 | 6, 7 | 6 (1), 7 (1) |
34 | The Tryptophan (TrpXYZ) Family | 1 | 1 | 8.0 ± 0 | 8 | 8 (1) |
35 | The Cobalamin precursor/Cobalt (CPC) Family | 2 | 2 | 5.7 ± 1 | 6 | 4 (2) 6 (2) 7 (2) |