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Table 1 Correlation between some relevant residues in E. coli CusA with the corresponding residues in the CzrA and NczA orthologs

From: Two RND proteins involved in heavy metal efflux in Caulobacter crescentus belong to separate clusters within proteobacteria

CusA

M271

M391

M403

M410

M486

M501

M573

M623

M672

M755

M1009

D405

E939

K984

CzrA

L301a

M420

I430

I437

L512

V527

Q598

A648

E699

A782

Q1031

D432

L972

V1006

NczA

L291

M410

I420

I427

L502

V517

H588

V638

E689

V722

Q1020

D422

L961

V995

Residue conserved b

--- (L)

M (M)

I/L (I/L)

I/V (I/V)

L (L)

---(V/I)

--- (−−-)

--- (−−-)

E (E)

--- (−−-)

Q ( Q )

D ( D )

L ( L )

V(V/I)

  1. aThe numbers correspond to the positions in C. crescentus CzrA and NczA proteins, respectively. The correspondence was determined by sequence alignment made using the PHYRE2 program [44].
  2. b Conservation profile within the CzrA-like proteins and in the NczA-like proteins (in parentheses). A conserved residue was considered the residue most prevalent (more than 75% conserved) in that position within the CzcA orthologous groups. In bold and italic are shown the residues absolutely conserved and ----- is not conserved.