Table 3 Microarray analysis of the genes that were downregulated in both gatifloxacin-resistant strains, 13124 R and NCTR R
Gene ID (name) | Function/Similarity | Microarray (mt/wt) | ||
|---|---|---|---|---|
| Â | Â | Â | NCTR | ATCC 13124 |
Biosynthesis of cofactors, prosthetic groups, and carriers | ||||
CPE1085 | CPF_1341 (ispH) | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase | −2.4 | −2.2 |
Energy metabolism | ||||
CPE0292 | CPF_0288 | carbohydrate kinase family protein | −3.1 | −2.5 |
CPE1185 | CPF_1389 (pfk) | 6-phosphofructokinase | −1.7 | −2.7 |
CPE0585 | CPF_0565 (fruB) | fructose-1-phosphate kinase | −5.2 | −2.3 |
CPE0692 | CPF_0684 | transaldolase | −2.8 | −2.3 |
CPE0725 | CPF_0721 (nanI) * | exo-alpha-sialidase | −3.5 | 1.5 |
CPE0894 | CPF_0887 (eutP) | ethanolamine utilization protein, EutP | −1.9 | −2.0 |
CPE2348 | CPF_2657 (ptb) | phosphate butyryltransferase | −2.3 | −1.6 |
Purine, pyrimidine, nucleotides, and nucleosides | ||||
CPE1398 | CPF_1652 (deoD) | purine nucleoside phosphorylase | −1.7 | −3.4 |
Regulatory functions | ||||
CPE0586 | CPF_0566 (fruR) | transcriptional regulator, DeoR family | −3.6 | −2.6 |
CPE0631 | CPF_0612 | probable PBP5 synthesis regulator protein | −2 | −2.5 |
CPE1077 | CPF_1333 | transcriptional regulator, PadR family | −3.1 | −3.2 |
CPE2510 | CPF_2833 | transcriptional regulator, PadR family | −2.6 | −2.7 |
CPE1305 | CPF_1512 | probable transcriptional regulator | −2 | −1.6 |
Transport and binding proteins | ||||
CPE0600 | CPF_0581 | amino acid ABC transporter | −4.8 | −3.4 |
CPE1534 | CPF_1785 | PTS system, sucrose-specific IIBC component | −3.1 | −14.3 |
CPE2345 | CPF_2654 | putative maltose/maltodextrin ABC transporter | −2.0 | −1.8 |
Unknown functions | ||||
CPE2509 | CPF_2832 | degV family protein | −3.6 | −3.3 |
CPE1171 | CPF_1374 | mutator mutT protein homolog | −6.4 | −2.0 |
CPE2592 | CPF_2917 | phnA family protein | −2. 8 | −2.0 |