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Table 2 Microarray analysis of the genes that were upregulated in one or both gatifloxacin-resistant mutants, 13124 R and NCTR R

From: Comparative transcription analysis and toxin production of two fluoroquinolone-resistant mutants of Clostridium perfringens

Gene ID and name Function/Similarity Microarray (mt/wt)
    NCTR ATCC 13124
Amino acid biosynthesis    
CPE1520 CPF_1772 (ilvE) branched-chain amino acid aminotransferase 1.1 2.6
CPE1905 CPF_2161 (dapA) dihydrodipicolinate synthase 1.0 1.9
Cell envelope
CPE0492 CPF_0465 capsular polysaccharide biosynthesis protein 6.5 1.9
CPE0495 CPF_0468 UDP-glucose/GDP-mannose dehydrogenase family 3.5 2.4
CPE2059 CPF_2316 putative membrane protein 7.1 3.2
CPE2079 CPF_2336 putative membrane protein 14.2 2.1
CPE0785 CPF_0787 putative membrane protein 2.3 2.1
Energy metabolism
CPE2186 CPF_2451 (atpE) ATP synthase epsilon subunit 3.3 2.9
CPE2187 CPF_2452 (atpB) ATP synthase beta subunit 3.6 2.2
CPE2189 CPF_2454 (atpA) ATP synthase alpha subunit 4.2 2.4
CPE2190 CPF_2455 (atpH) ATP synthase delta subunit 1.9 2.1
CPE2191 CPF_2456 (atpF) ATP synthase B chain 2.2 2.3
CPE2192 CPF_2457 (atpL) ATP synthase C chain 3.6 2.3
Fatty acid and phospholipid metabolism
CPE1068 CPF_1324 (fabH) 3-oxoacyl-(acyl-carrier-protein) synthase III 2.2 4.7
CPE1069 CPF_1325 (fabD) malonyl CoA-acyl carrier protein transacylase 1.1 3.6
CPE1071 CPF_1327 (fabF) 3-oxoacyl-(acyl-carrier-protein) synthase II 1.3 3.8
CPE1072 CPF_1328 (accB) acetyl-CoA carboxylase, biotin carboxyl carrier 0.9 4.0
CPE1073 CPF_1329 (fabZ) beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ 1.0 4.5
CPE1074 CPF_1330 (accC) acetyl-CoA carboxylase, biotin carboxylase 1.7 4.9
CPE1075 CPF_1331 (accD) acetyl-CoA carboxylase, carboxyl transferase, beta subunit 3.4 5.0
CPE1076 CPF_1332 (accA) acetyl-CoA carboxylase, carboxyl transferase, alpha subunit 1.9 4.6
Protein synthesis
CPE1697 CPF_1951 (frr) ribosome recycling factor 1.1 2.0
CPE2441 CPF_2720 ribosomal protein L7AE family 1.1 2.6
CPE2660 CPF_2997 (rpmH) ribosomal protein L34 1.4 2.0
Purine, pyrimidine, nucleotides, and nucleosides
CPE1050 CPF_1305 (mtnH) 5-methylthioadenosine/S-adenosylhomocysteine nuclosidase 3.2 2.6
CPE2162 CPF_2418 (cpdC) 2`,3`-cyclic-nucleotide 2`-phosphodiesterase 3.4 1.6
Transport and binding proteins
CPE0977 CPF_1235 potassium transporter 7.1 2.9
Unknown functions
CPE2601 CPF_2928 conserved hypothetical protein 6.7 58.0
  1. All of the data are the means of three different experiments.
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