Nucleotide substitutions in dengue virus serotypes from Asian and American countries: insights into intracodon recombination and purifying selection

Table 3 Codon usage bias in dengue virus

DENV-1	RSCU > 1 in Asian DENV	RSCU < 1 in Asian DENV	p value
RSCU > 1 in American DENV	91	160	0.02
RSCU <1 in American DENV	193	112
DENV-2	RSCU > 1 in Asian DENV	RSCU < 1 in Asian DENV
RSCU > 1 in American DENV	35	121	0.000004
RSCU <1 in American DENV	155	79
DENV-3	RSCU > 1 in Asian DENV	RSCU < 1 in Asian DENV
RSCU > 1 in American DENV	80	132	0.08
RSCU <1 in American DENV	138	116
DENV-4	RSCU > 1 in Central American DENV	RSCU <1 in South American DENV
RSCU > 1 in Central American DENV	5	13	0.004
RSCU <1 in South American DENV	22	16

Number of synonymous codons that are used either more than expected (frequent) or less than expected (rare) between Asian and American isolates of DENV serotype 1, 2 and 3 (or between South and Central American isolates of DENV4).

ISSN: 1471-2180