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Table 1 Number of synonymous and non-synonymous changes in DENV serotypes

From: Nucleotide substitutions in dengue virus serotypes from Asian and American countries: insights into intracodon recombination and purifying selection

Category

Position 1

Position 2

Position 3

Codons

DENV1-Syn

152

0

1333

1420

DENV1-Nonsyn

128

112

129

244

DENV2-Syn

120

0

1212

1281

DENV2-Nonsyn

109

96

111

211

DENV3-Syn

121

0

1129

1197

DENV3-Nonsyn

102

117

100

218

DENV4-Syn

112

0

1259

1370

DENV4-NonSyn

102

103

109

314

  1. Dengue virus serotypes are listed as DENV1, DENV2, DENV3 and DENV4. Syn: synonymous changes. Nonsyn: non-synonymous changes. Position 1/2/3: 1st, 2nd and 3rd positions of codons. For synonymous changes, the 3rd position substitutions are predominant as expected. However, for non-synonymous changes, all the three positions of codons undergo changes with no significant bias with any specific position. Number of codons associated with non-synonymous (Non-syn) or synonymous (Syn) changes in each serotype are shown in the last column.