Table 11 Functionally characterized Sco and Mxa proteins
Protein designation; Sco# or Mxan#, and reference1 | UniProt Acc# | TC# | Probable or established function |
|---|---|---|---|
S. coelicolor | |||
MscL; Sco3190 [102] | Q9KYV5 | 1.A.22.1.10 | MscL, osmotic adaptation channel that influences sporulation and secondary metabolite production. |
GlcP1/2; Sco7153; Sco5578 [103] | Q7BEC4 | 2.A.1.1.35 | MFS major glucose uptake porters (two identical sequences at the AA level, and having a single substitution on the NT level). |
MdrA; Sco4007 [104] | Q9ADP8 | 2.A.1.36.4 | Putative MDR transporter; may export hydrophobic cationic compounds. |
PitH1 and 2; Sco4138 and Sco1845 [105] | Q9KZW3, Q9RJ23 | 2.A.20.1.5 and 6 | Two putative low-affinity inorganic phosphate (Pi) uptake porters. |
DasABC: Sco5232-4 (R, M, M). MsiK: Sco4240 (C) [106] | Q9K489-91,Q9L0Q1 | 3.A.1.1.33 | DasABC/MsiK; system for the uptake of chitin-degradation products. |
Agl3EFG porter (R, M, M; Sco7167-Sco7165 [107]; Agl3K (C; unknown) | Q9FBS7-5 | 3.A.1.1.43 | Sugar uptake porter; induced by trehalose and melibiose using a GntR transcription factor. May use the MsiK ATPase [106]. |
MalEFG; Sco2231-Sco2229 (R, M, M) [108]; MalK (C) unknown. | Q7AKP1, Q9KZ07-8 | 3.A.1.1.44 | Sugar uptake porter; involved in maltose and maltodextrin uptake. May use the MsiK ATPase [106]. |
XylFGH. | O50503-5 | 3.A.1.2.24 | Xylose uptake porter; transcriptionally regulated by a GntR-type protein, ROK7B7. |
XylF, Sco6009 (R; 1 N-terminal TMS); | |||
XylG, Sco6010 (C; ATP-binding, no TMSs); | |||
XylH, Sco6011 (M; 12 TMSs); [109] | |||
Probable ABC peptide uptake porter; Sco5476-80 (M, R, M, C, C) [110] | O86571-5 | 3.A.1.5.34 | Probably takes up a peptide involved in the regulation of sporulation and secondary metabolite production. |
Sco5117-Sco5121 (R, M, M, C, C) [111] | Q9F353-49 | 3.A.1.5.35 | Probable oligopeptide uptake porter. |
BldKA-D and Sco5116; Sco5112-6 (M, R, M, C, C) [112] | Q93IU3-0; Q8CJS2 | 3.A.1.5.36 | BldKA-D and Sco5116; peptide uptake porter induced by S-adenosylmethionine. |
DesABC; Sco7499-8, Sco7400 (R, M-M, C) [113] | Q9L177-9 | 3.A.1.14.12 | Desferrioxamine B uptake porter. |
CchCDEF; Sco0497-4 (M, M, C, R) [113] | Q9RK09-12 | 3.A.1.14.13 | Ferric iron-coelichelin uptake porter. |
DesEFGH; Sco2780 (R), Sco1785-7 (C, M, M) [113] | Q9L07; Q9S215-3 | 3.A.1.14.22 | Putative ferric iron-desferrioxamine E uptake porter. |
SclAB; Sco4359-60 (C, M) [114] | Q9F2Y8-7 | 3.A.1.105.13 | SclAB transporter; confers acyl depsipeptide (ADEP) resistance. ADEP has antibiotic activity. |
RagAB; Sco4075-4 (C, M) [115] | Q7AKK4-5 | 3.A.1.105.14 | RagAB exporter; involved in both aerial hyphae formation and sporulation. |
SoxR regulon ABC exporter; Sco7008 (M, C) [116] | Q9KZE5 | 3.A.1.106.9 | Putative SoxR-regulated drug exporter; SoxR responds to extracellular redox-active compounds such as actinorhodin. |
AreABCD; Sco3956-9 (C, M, C’, M’) [117] | Q9ZBX6-3 | 3.A.1.146.1 | Putative drug exporter; possibly specific for actinorhodin (ACT) and undecylprodigiosin (RED). |
H+-PPase; Sco3547 [118] | Q6BCL0 | 3.A.10.2.2 | H+-translocating inorganic pyrophosphatase. |
M. xanthus | |||
MmrA; MXAN_5906 [119] | Q1CZY0 | 2.A.1.2.83 | Homologous to drug exporter; possibly involved in amino acid uptake and antimicrobial export. |
TatABC; MXAN_2960, MXAN_5905-4, [120] | Q1D854, Q1CZY1-2 | 2.A.64.1.2 | Twin arginine targeting protein translocase. |
RfbAB; MXAN_4623-2 (M, C) [121] | Q1D3I2-3 | 3.A.1.103.4 | Putative lipopolysaccharide exporter. |
AbcA; MXAN_1286 (M-C) [122] | Q1DCT0 | 3.A.1.106.10 | AbcA; involved in molecular export; required for the autochemotactic process. |
PilGHI; MXAN_5782-0 (R, C, M) [123] | O30384-6 | 3.A.1.144.5 | Necessary for social motility, pilus assembly and pilus subunit (PilA) export. |