Figure 2

Environmental isolates exhibit different fractions of persisters after treatment with ciprofloxacin or nalidixic acid. The plots show six replicates for each of the three strains shown in Figure 1. A: Killing dynamics during 48 hours of treatment with ciprofloxacin. Biphasic dynamics, similar to those observed in Figure 1, are observed. B: Killing dynamics during 48 hours of treatment with nalidixic acid. There are large differences in persister fractions between the two antibiotics, with strain SC649 exhibiting a low fraction of persisters in ciprofloxacin, but a high fraction in nalidixic acid.