Table 1 Host genes identified from shRNAmir kinome screen required for Y. enterocolitica mediated knock-down of NF-κB activation
From: c-KIT signaling is targeted by pathogenic Yersiniato suppress the host immune response
Gene name | Accession # | Function |
|---|---|---|
ABL | NM_005157 | Regulation of cell differentiation and adhesion |
ACTR-IIB | NM_001106 | Activin and myostatin signaling involved in apoptosis, inflammation |
CKII | NM_177560 | Regulation of metabolic pathways, signal transduction, transcription |
ERK4/MAPK7 | NM_139033 | Signaling of receptor kinases and G protein-coupled receptors |
GNE/DMRV | NM_005476 | Rate-limiting enzyme in sialic acid biosynthesis |
HSPH1 | NM_006644 | Reduces protein aggregation and cytotoxicity through induction of HSP70 |
c-KIT | NM_000222 | Differentiation of hematopoietic progenitor cells and mast stem cells |
MAP3K3 | NM_002401 | Regulation of NF-κB gene expression |
MEK1 | NM_002755 | MAPK signal transduction pathways involved in transcription regulation |
MONaKA/PXK | NM_017771 | Binds to and modulates Na,K-ATPase enzymatic and ion pump activities |
NIK/MAP3K14 | NM_003954 | Activates NF-κB in response to TNFR and IL-1R signaling |
PAK4 | NM_005884 | Inactivates actin binding/depolymerizing factor cofilin |
PIK3R2 | NM_005027 | PI3K/Akt signaling associated with cell survival, proliferation |
PI3-K-C2A | NM_002645 | Member of the PI3K family, potential role in integrin-dependent signaling |
SGK1 | NM_005627 | Regulation of cell stress response through activation of ion channels |
SGK2 | NM_170693 | Regulates ion channels in response to signals that activate PI3K |
ULK2 | NM_014683 | Stress response, mediates mTOR signaling in autophagy |
WNK1 | NM_018979 | Regulator of blood pressure by activating ion channel transporters |
WNK3 | NM_020922 | Positive regulator of the transcellular Ca2+ transport pathway |