TY - JOUR AU - Yin, Yeshi AU - Damron, F. Heath AU - Withers, T. Ryan AU - Pritchett, Christopher L. AU - Wang, Xin AU - Schurr, Michael J. AU - Yu, Hongwei D. PY - 2013 DA - 2013/10/18 TI - Expression of mucoid induction factor MucE is dependent upon the alternate sigma factor AlgU in Pseudomonas aeruginosa JO - BMC Microbiology SP - 232 VL - 13 IS - 1 AB - Alginate overproduction in P. aeruginosa, also referred to as mucoidy, is a poor prognostic marker for patients with cystic fibrosis (CF). We previously reported the construction of a unique mucoid strain which overexpresses a small envelope protein MucE leading to activation of the protease AlgW. AlgW then degrades the anti-sigma factor MucA thus releasing the alternative sigma factor AlgU/T (σ22) to initiate transcription of the alginate biosynthetic operon. SN - 1471-2180 UR - https://doi.org/10.1186/1471-2180-13-232 DO - 10.1186/1471-2180-13-232 ID - Yin2013 ER -