Figure 1From: Poly-L-glutamate/glutamine synthesis in the cell wall of Mycobacterium bovisis regulated in response to nitrogen availabilityPictorial representation depicting role of glutamine synthetase in nitrogen metabolism and PLG synthesis. In low nitrogen conditions GlnR acts as a positive regulator and activates transcription of glnA1 gene. In high nitrogen conditions GlnE acts as a negative regulator and adenylylated GS protein, which thus becomes inactive. GS, glutamine synthetase; ↑↑↑, up-regulation.Back to article page