Table 4 Top-ten consistently perturbed gene sets
Gene set | Genes |
|---|---|
Up-regulated | |
Adaptive immune response (MsigDB) | MALT1 |
Dissolution of fibrin clot (NCI) | SERPINE1, PLAUR |
Granulocytes pathway (BIOCARTA) | ICAM1, IL8, IL1A |
Inactivation of MAPK activity (MsigDB) | DUSP8, DUSP6, SPRED2 |
Viral genome replication (MsigDB) | TNIP1, CCL2, IL8 |
Hedgehog pathway up (NETPATH) | PMP22, THBD, MYC |
Positive regulation of immune response (MsigDB) | FYN, EREG, MALT1 |
CD28 dependent PI3K AKT signaling (REACTOME) | MAP3K14, FYN, TRIB3, MAP3K8 |
Peptidyl tyrosine phosphorylation (MsigDB) | CLCF1, STAT1, IL12A, LYN |
CDMAC pathway (BIOCARTA) | NFKB1, NFKBIA, FOS, MYC, RELA |
Down-regulated | |
LSM1-7 complex (CORUM) | LSM4, LSM6, LSM2, LSM7 |
Respiratory chain complex I incomplete intermediate mitochondrial (CORUM) | NDUFS6, NDUFV2, NDUFS4, NDUFS7 |
Mitochondrial respiratory chain (MsigDB) | UQCRC1, NDUFAB1, BCS1L, NDUFS4, NDUFS7, NDUFS3, NDUFS8, SURF1 |