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Table 4 Top-ten consistently perturbed gene sets

From: Computational approaches for discovery of common immunomodulators in fungal infections: towards broad-spectrum immunotherapeutic interventions

Gene set Genes
Up-regulated
Adaptive immune response (MsigDB) MALT1
Dissolution of fibrin clot (NCI) SERPINE1, PLAUR
Granulocytes pathway (BIOCARTA) ICAM1, IL8, IL1A
Inactivation of MAPK activity (MsigDB) DUSP8, DUSP6, SPRED2
Viral genome replication (MsigDB) TNIP1, CCL2, IL8
Hedgehog pathway up (NETPATH) PMP22, THBD, MYC
Positive regulation of immune response (MsigDB) FYN, EREG, MALT1
CD28 dependent PI3K AKT signaling (REACTOME) MAP3K14, FYN, TRIB3, MAP3K8
Peptidyl tyrosine phosphorylation (MsigDB) CLCF1, STAT1, IL12A, LYN
CDMAC pathway (BIOCARTA) NFKB1, NFKBIA, FOS, MYC, RELA
Down-regulated
LSM1-7 complex (CORUM) LSM4, LSM6, LSM2, LSM7
Respiratory chain complex I incomplete intermediate mitochondrial (CORUM) NDUFS6, NDUFV2, NDUFS4, NDUFS7
Mitochondrial respiratory chain (MsigDB) UQCRC1, NDUFAB1, BCS1L, NDUFS4, NDUFS7, NDUFS3, NDUFS8, SURF1
  1. Top-ten consistently perturbed gene sets, ranked by the number of genes they contain for up- and down- regulated gene sets.