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Figure 2 | BMC Microbiology

Figure 2

From: Bactericidal activity of PA-824 against Mycobacterium tuberculosis under anaerobic conditions and computational analysis of its novel analogues against mutant Ddn receptor

Figure 2

M. tuberculosis pathways associated with the dosage optimization for PA- 824 treatment. Excess NO release during elevated PA-824 concentrations could favor M. tuberculosis antioxidant defense mechanism involving trHbN and down regulation of autophagy. Hence dose optimization of PA-824 therapy is a key parameter for successful killing of the pathogen.

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BMC Microbiology

ISSN: 1471-2180

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