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Figure 4 | BMC Microbiology

Figure 4

From: Selective photoinactivation of Candida albicans in the non-vertebrate host infection model Galleria mellonella

Figure 4

Killing of G. mellonella larvae after infection by C. albicans Can37 fluconazole resistant. The larvae received an injection of 1.4x106CFU/larva and were maintained at 37°C. a) administration of fluconazole (14 mg/kg) or PBS (Control), b) antimicrobial PDT or only MB (Control), c) administration of fluconazole followed by aPDT in a combined therapy or PBS (Control), d) administration of aPDT followed by fluconazole in a combined therapy or PBS (Control), e) administration of aPDT or fluconazole + PDT, f) administration of aPDT or fluconazole + PDT. There was no significant difference on larvae survival when treatment was done only by injecting of fluconazole (P = 0.584) or aPDT alone (P = 0.102). The combined treatment by application of aPDT followed or before fluconazole injection resulted in significantly lower death rates when compared to a control groups (P = 0.0010 to aPDT followed by fluconazole, and P = 0.0018 when aPDT was applied after fluconazole injection). A significant difference in survival was observed for combined treatment compared to aPDT alone (P = 0.0062 for aPDT followed by fluconazole, and P = 0.0068 when aPDT was applied after fluconazole injection).

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