Thermal inactivation kinetics of HAV. Thermal Inactivation kinetics of HAV (a,b,c), expressed with the log-linear + tail model: log10(S
(t)) = log10((Si,0 − Si,res) · exp(−kmax · t) + Si,res) (Equation 2). Plots of the estimated parameters for Equation 2 and the corresponding 95% asymptotic confidence intervals for HAV. (a) Si,0; (b) kmax; (c) Si,res. The results obtained at 37°C, 68°C, 72°C and 80°C are indicated by ▼, ■, ● and ◆ respectively. Symbol shaded in gray indicates data obtained with cell culture method, symbol in black indicates RT-qPCR and open symbol represents RT-qPCR with pre-treatment. (- -) Limit of quantification.