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Table 1 MIC data for lacticin 3147, polymyxin B and polymyxin E alone and in combination

From: The two peptide lantibiotic lacticin 3147 acts synergistically with polymyxin to inhibit Gram negative bacteria

Organism MIC (μg/ml)
  Lacticin 3147 Polymyxin B Polymyxin E Lacticin 3147/ FIC Lacticin 3147/ FIC
     Polymyxin B   Polymyxin E  
Salmonella Typhimurium UK1 924 0.0586 0.0586 924/0.015 1.25d 924/0.0073 1.125d
Salmonella Typhimurium LT2 231 0.3125 0.4688 No MIC >4e No MIC >4e
Cronobacter sakazakii DPC 6440 >924 0.3125 0.3125 57.75/0.0781 0.250 (<0.312)*a 57.75/0.0195 0.062 (<0.125)*a
E. coli 0157:H- 231 0.0586 0.0781 28.875/0.0073 0.250a 28.875/0.0049 0.188a
E. coli DH5α 462 0.0781 0.0781 28.875/.0098 0.188a 28.875/0.0098 0.188a
E. coli EC101 462 0.0781 0.0781 14.4375/.0391 0.5a 28.875/0.0098 0.188a
E. faecium DO 0.9625 >375 >375 0.9625/23.4375 1c 0.9652/23.4375 1c
B. cereus 8079 3.85 187.5 375 1.925/23.4375 0.62b 3.85/375 2d
S .aureus 5247 15.4 187.5 >375 7.7/46.875 0.75b 15.4/23.4375 1c
  1. FIC figures have been calculated as a result of triplicate experiments and indicate asynergy, bfor partial synergy, cadditive effects, dindifference, and eantagonism between the combined antimicrobials. *FIC index which includes the reduction in lacticin 3147 MIC from the highest level tested to that which achieves an MIC in the presence of polymyxin.