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Table 2 TNF-α secretion of LPS-stimulated J774 cells infected with F. tularensis

From: The Francisella tularensis LVS ΔpdpCmutant exhibits a unique phenotype during intracellular infection

Strain

TNF-α secretion (pg/ml)a

-

708 ± 102

LVS

45.9 ± 8.9***

ΔpdpC

36.4 ± 7.5***

ΔiglA

1340 ± 126

  1. aF. tularensis-infected, or uninfected (-), J774 cells were incubated for 2 h with LPS. The average TNF-α secretion in pg/ml with standard errors of triplicate samples is shown, results are from one representative experiment out of three. A Student’s t-test revealed that there was no significant difference in TNF-α secretion between LVS and ΔpdpC mutant infected cells, but that cells infected with either strain had a significantly lower TNF-α secretion than uninfected cells (***: P < 0.001).
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BMC Microbiology

ISSN: 1471-2180

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