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Table 1 Activity of the naphthoquinones on bloodstream trypomastigotes of T. cruzi at 37°C

From: Trypanosoma cruzi mitochondrial swelling and membrane potential collapse as primary evidence of the mode of action of naphthoquinone analogues

Cpd Nomenclaturea IC50/24 h (μM)
NQ1 1,4-Naphthoquinone 0.79 ± 0.02
NQ2 2-Methyl-1,4-naphthoquinone (menadione) 6.04 ± 0.35
NQ3 2-Hydroxy-1,4-naphthoquinone (lawsone) 563.18 ± 83.28
NQ4 2-Acetoxy-1,4-naphthoquinone 63.02 ± 5.8
NQ5 2-Bromo-1,4- naphthoquinone 1.37 ± 0.03
NQ6 2,3-Dichloro-1,4- naphthoquinone (dichlone) 2.17 ± 0.29
NQ7 5-Hydroxy-1,4-naphthoquinone (juglone) 6.51 ± 0.48
NQ8 5-Acetoxy-1,4- naphthoquinone 0.16 ± 0.01
NQ9 5-Methoxy-1,4-naphthoquinone 1.02 ± 0.29
NQ10 2-Bromo-5-hydroxy-1,4-naphthoquinone 2.15 ± 0.22
NQ11 2-Bromo-5-acetoxy-1,4-naphthoquinone 2.43 ± 0.50
NQ12 2-Bromo-5-methoxy-1,4-naphthoquinone 1.25 ± 0.26
NQ13 3-Bromo-5-hydroxy-1,4-naphthoquinone 2.52 ± 0.37
NQ14 3-Bromo-5-acetoxy-1,4-naphthoquinone 0.85 ± 0.08
NQ15 3-Bromo-5-methoxy-1,4-naphthoquinone 1.41 ± 0.15
NQ16 2-Methyl-5-hydroxy-1,4-naphthoquinone (plumbagin) 1.38 ± 0.26
Bz Benznidazole 26.0 ± 4.0
  1. aThe bromo derivatives (NQ10-NQ15) are named based on the core juglone (NQ7) system.