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Figure 5 | BMC Microbiology

Figure 5

From: Trypanosoma cruzi mitochondrial swelling and membrane potential collapse as primary evidence of the mode of action of naphthoquinone analogues

Figure 5

Transmission electron microscopy analysis of T. cruzi epimastigotes treated with NQ12. (A-E) Parasites treated with 0.5 μM showed a strong mitochondrial swelling (*) with membranous structures in the organelle matrix (black arrows), the formation of flagellar blebs (thick black arrows) and the appearance of endoplasmic reticulum in close contact with the reservosome membranes (white arrows). An intense vacuolization (V) and washed out aspect of the cytosol (black star) were also detected after treatment with NQ12. Bars = 500 nm (A, C-E) and 200 nm (B).

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