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Table 5 IC 50 values (μM) of trifluorothymidine (TFT) and 5-fluorodeoxyuridine (5FdU) with purified recombinant human TK1 and TK2, Ureaplasma TK, and Mpn extracts *

From: Inhibition of Mycoplasma pneumoniae growth by FDA-approved anticancer and antiviral nucleoside and nucleobase analogs

 

TFT

5FdU

P value

Human TK1

9.7 ± 3.2

75.9 ± 2.6

<0.0001

Human TK2

80 ± 5.6

158.5 ± 2.7

<0.0001

Ureaplasma TK

12.0 ± 4.2

1000 ± 13.3

<0.0001

Mpn extracts

9.1 ± 2.9

47.9 ±1.2

<0.0001

  1. *Assays were performed with 10 μM tritium labelled thymidine as substrate in the presence of various concentrations of the inhibitors. Data were mean ± SD from at least three independent determinations. P value < 0.05 is considered as significant.
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BMC Microbiology

ISSN: 1471-2180

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