|
Compounds
|
Wild type MIC (μg ml-1)
|
thyA mutant MIC (μg ml-1)
|
|---|
|
Ribavirin
|
62.5
|
> 500
|
|
Pentoxifylline
|
62.5
|
> 500
|
|
Gancyclovir
|
7.8
|
> 500
|
|
Zidovudine
|
7.8
|
7.8
|
|
Gemcitabine (dFdC)
|
2.4
|
2.4
|
|
Stavudine
|
7.8
|
17.8
|
|
Acyclovir
|
15.6
|
15.6
|
|
Pyrimethamine
|
> 500
|
> 500
|
|
Fludarabine phosphate
|
> 500
|
> 500
|
|
Lamivudine
|
> 500
|
> 500
|
|
Mycophenolate mofetil
|
250
|
250
|
|
Trifluorothymidine (TFT)
|
1.8
|
1.8
|
|
Adefovir depivoxil
|
> 500
|
> 500
|
|
5-azacytidine
|
> 500
|
> 500
|
|
Azathioprine
|
> 500
|
> 500
|
|
Arabinosyl adenine
|
> 500
|
> 500
|
|
Zalcitabine
|
> 500
|
> 500
|
|
5-iododeoxyuridine
|
15.6
|
> 500
|
|
5-fluorodeoxyuridine (5FdU)
|
7.8
|
15.6
|
|
Cidofovir
|
31.2
|
31.2
|
|
Caffeine
|
> 500
|
> 500
|
|
7-(2,3-dihydroxypropyl)theophylline
|
> 500
|
> 500
|
|
Theophylline
|
> 500
|
> 500
|
|
6-thioguanine (6-TG)
|
0.2
|
0.2
|
|
Allopurinol
|
> 500
|
> 500
|
|
6-mercaptopurine (6-MP)
|
> 500
|
> 500
|
|
5-fluorouracil
|
31.2
|
31.2
|
|
5-fluorocytosine
|
31.2
|
31.2
|
|
Valacyclovir
|
> 500
|
> 500
|
|
Dipyridamole
|
1.9
|
1.9
|
- *MIC = minimal concentrations of the compound that produced 90% inhibition.
