Staphylococcus aureus but not Listeria monocytogenes adapt to triclosan and adaptation correlates with increased fabI expression and agr deficiency

Table 2 Aminoacid substitutions in FabI of USA300 strains passaged either in the absence (C1 and C2) or presence (A1 through A7) of triclosan compared to the genome sequence (34)

Aminoacid number (from gene start)	A1	A2	A3	A4	A5	A6	A7
Upstream of *fabI*
−74						M → R
−32					I → T
−19							V → D
*fabI*
24	A → T
101						D → Y
193		I → F	I → F
204	F → L			F → S	F → C	F → C

Minus positions are upstream of the protein start. Abbreviations for amino acids are: M Methionine, R Arginine, I Isoleucine, T Threonine, V Valine, D aspartic acid, A alanine, N asparagine, F Phenyl alanine, C cysteine, L Leucine, S Serine.

ISSN: 1471-2180