TY - JOUR AU - Piatek, Rafał AU - Zalewska-Piatek, Beata AU - Dzierzbicka, Krystyna AU - Makowiec, Sławomir AU - Pilipczuk, Justyna AU - Szemiako, Kasjan AU - Cyranka-Czaja, Anna AU - Wojciechowski, Marek PY - 2013 DA - 2013/06/12 TI - Pilicides inhibit the FGL chaperone/usher assisted biogenesis of the Dr fimbrial polyadhesin from uropathogenic Escherichia coli JO - BMC Microbiology SP - 131 VL - 13 IS - 1 AB - The global spread of bacterial resistance has given rise to a growing interest in new anti-bacterial agents with a new strategy of action. Pilicides are derivatives of ring-fused 2-pyridones which block the formation of the pili/fimbriae crucial to bacterial pathogenesis. They impair by means of a chaperone-usher pathway conserved in the Gram-negative bacteria of adhesive structures biogenesis. Pili/fimbriae of this type belong to two subfamilies, FGS and FGL, which differ in the details of their assembly mechanism. The data published to date have shown that pilicides inhibit biogenesis of type 1 and P pili of the FGS type which are encoded by uropathogenic E. coli strains. SN - 1471-2180 UR - https://doi.org/10.1186/1471-2180-13-131 DO - 10.1186/1471-2180-13-131 ID - Piatek2013 ER -