Extracellular DNA-induced antimicrobial peptide resistance in Salmonella enterica serovar Typhimurium

BMC Microbiology

Table 1 Extracellular DNA induces antibiotic resistance in S. Typhimurium

Strain	Minimal inhibitory concentration (MIC)
Strain	Polymyxin B		Colistin		Gentamicin		Ciprofloxacin
	-	+ DNA^a	-	+ DNA^a	-	+ DNA^a	-	+ DNA^a
14028	1	16	1	16	0.125	0.5	0.125	>0.5
phoPQ	1	0.5	1	1	0.125	0.25	0.125	>0.5
ΔpmrAB	0.5	0.5	0.5	0.5	0.125	0.5	0.125	>0.5

^a The minimal inhibitory concentration (MIC) values were determined in NM2 medium containing 1 mM Mg²⁺ (pH 7.4) with or without the addition of 0.5% fish sperm DNA-sodium salt (5 mg/ml).

ISSN: 1471-2180