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Table 3 Diversity of cassette arrays detected among class 1 and class 2 integrons

From: Analysis for prevalence and physical linkages amongst integrons, ISEcp1, ISCR1, Tn21 and Tn7 encountered in Escherichia coli strains from hospitalized and non-hospitalized patients in Kenya during a 19-year period (1992–2011)

 

Distribution [number, (%)] of cassette arrays of cassette arrays in different types of integrons

 

Resistance to selected antimicrobials in randomly selected strains carrying a given integron array

Classes of antimicrobials to which the host strain was resistanta

Prevalence among isolates with integrons (n = 464)

Integrons containing 3’-CS

Integrons lacking 3’-CS

Class 1 integrons arrays

     

dfrA1

TRIM, SUL, TET,

2 to 4

60 (13)

53 (88)

7 (12)

dfrA1/aadA1

TRIM, STP, AMP, C, CTX, CAZ, CIP, NA

5 to 8

51 (11)

42 (82)

9 (18)

dfrA17/aadA5

TRIM, STP, C, AMP, C, CTX, CAZ, CIP, NA, FOX, AMC

5 to 8

42 (9)

34 (81)

8 (19)

dfrA7

TRIM, SMX, TET

2 to 8

42 (9)

35 (83)

7 (17)

aadA1

STP, C, TET, SUL

2 to 6

23 (5)

19 (83)

4 (17)

dfrA12/aadB

TRIM, STRP, CN, K, TOB, AMP, C, CTX, AMC

4 to 8

23 (5)

19 (83)

4 (17)

dfrA16/aadA2

TRIM, STP, K, TOB, AMP, C, CTX, AMC

6 to 8

23 (5)

22 (96)

1 (4)

aadA2/dfrA12

STP, TRIM, TET, C, SUL, AMP, CTX, AMC,

3 to 6

28 (6)

26 (93)

2 (7)

dfrA12/aadA2

TRIM, STP, TET, C, SUL

3 to 8

23 (5)

22 (96)

1 (4)

aadA5

STP, AMP, SUL, TET

7 to 8

23 (5)

22 (96)

1(4)

blaoxa-1/aadA1

STP, AMP, C, TET, CTX, CAZ, CIP, NA, FOX, AMC

8

23 (5)

22 (94)

1 (4)

blaoxa-1/aadA2

STP, AMP, C, TET, CTX, CAZ, CIP, NA, FOX, AMC

7 to 8

9 (2)

8 (88)

1 (12)

dfrA12/orfF/aadA2

TRIM, STP, C, TET, CTX, NA, AMC

6 to 8

9 (2)

8 (88)

1 (12)

aac(6')Ib/catB1/dfrA1

CN, TOB, C, TRIM, K, AMP, C, TET, CTX, CAZ, CIP, NA,

5 to 8

9 (2)

7 (78)

2 (22)

aadA1/dfrA1

STP, TRIM, AMP, C, TET, CTX, NA, AMC

3 to 8

9 (2)

9 (100)

0

aac(6')Ib/blaoxa-1/catB3/arr2

CN,TOB, K, C, RIF, AMP, C, TET, CTX, CAZ, CIP, NA, FOX, AMC

8

9 (2)

2 (22)

7 (78)

aadA2/orfF/dfrA12

STP, AMP, TRIM, SUL, TET

7 to 8

5 (1)

4 (80)

1 (20)

cmlA1

C,, TET, CTX, NA, AMP

3 to 8

3 (<1)

3 (100)

0

orf5/dfrB/orfA

TRIM, CN,TOB, C, AMP, C, TET, CTX, CAZ, CIP, NA, AMC

6

3 (<1)

0

3 (100)

dfrA12/aadA1/blaoxa1

TRIM, STP, CN,TOB, AMP, C, TET, CTX, CAZ, CIP, NA,

8

5 (1)

0

5 (100)

aac(6')-lb-cr

CN, K, TOB, C, AMP, C, TET, CTX, CAZ, CIP, NA, AMC

8

42 (9)

15 (36)

27 (64)

Class 2 Integron arrays

     

drfA1/sat2/aadA1

TRIM, STRP, CN, K, TOB, AMP, C, CTX, AMC

6 to 8

3 (<1)

NA

NA

  1. The integron cassette arrays are indicated in the order they appear within class 1 and 2 integron variable cassette region (in the 5’-3’ orientation).
  2. The resistance phenotype associated with a given array is indicated in bold.
  3. a: Different antimicrobials tested in this study were conveniently grouped into 8 groups:- β-lactams and β-lactamase inhibitors, aminoglycosides, (fluoro)quinolones, nitrofurantoin, chloramphenicol, sulphonamides, trimethoprim, and tetracyclines.
  4. b: These integrons carried a sul3 gene at the 3’-end or lacked this gene or 3’-CS comprising the qacEΔ1-sul1 genes.