Domain architecture of the WD0766 ANK domain protein in Wolbachia strains. The location of ANK motifs (coloured boxes with numbers) was determined using SMART v3.5 (http://smart.embl-heidelberg.de/). Transmembrane domains (black boxes) were predicted using the TMHMM2 server. The presence of a frameshift in the wAu and wWil WD0766 gene creates a premature stop (*) that prevents the translation of the transmembrane domains. The wSan, wYak and wTei genes also contain a premature stop (*) that prevents the translation of 6 ANK domains and two transmembrane domains. These genes also contain an IS5 element insertion inside the 10th ANK domain. Some of the ANK repeat motifs are duplicated (d). The colour scheme corresponds to the DNA sequence similarity of the ANK repeat motifs (Figure 5).