katG
|
wild type
|
65
|
4(1)
|
|
Ala291Thr (gct/act); Ser315Thr (agc/acc)
| |
1
|
|
Trp300Cys (tgg/tgc)
| |
1
|
|
Thr302Arg (acg/agg)
| |
1
|
|
Ser315Thr (acg/acc)
| |
21
|
|
Asp329 (gac/ggac frameshift)
| |
1
|
|
Arg463Leu (cgg/ctg)(2)
| |
2
|
|
Gln471Arg (cag/cgg); Ser315Thr (agc/acc)
| |
1
|
|
Strains phenotypically susceptible to RIF (n=)
|
Strains phenotypically resistant to RIF (n=)
|
rpoB
|
wild type
|
76
| |
|
Thr481Ala (acc/gcc)(3)
| |
1
|
|
Leu511Pro (ctg/ccg)(4)
|
1
| |
|
Asp516Tyr (gac/tac)(4)
|
3
| |
|
His526Tyr (cac/tac)
| |
3
|
|
His526Arg (cac/cgc)
| |
3
|
|
Ser531Leu (tcg/ttg)
| |
8
|
|
Leu533Pro (ctg/ccg)(4)
|
1
|
1
|
|
Strains phenotypically susceptible to SM (n=)
|
Strains phenotypically resistant to SM (n=)
|
rpsL
|
wild type
|
56
|
21
|
|
Lys43Arg (aag/agg)
| |
11
|
|
Lys88Arg (aag/agg)
|
1
|
8
|
gidB
|
wild type
|
26 (2 with mutations in rrs/rpsL)
|
15 (10 with mutations in rpsL)
|
|
Leu16Arg (ctt/cgt)
|
4
|
2
|
|
Leu16Arg (ctt/cgt); Gln127stop (caa/taa); Ala161Ala (gcc/gcg)
|
1
| |
|
Leu16Arg (ctt/cgt); Ala161Ala (gcc/gcg)
|
2
|
1 (Lys43Arg in rpsL)
|
|
Leu16Arg (ctt/cgt); Ala200Glu (gcg/gag)
| |
2
|
|
Leu16Arg (ctt/cgt); Ala205Ala (gca/gcg)
| |
1 (Lys43Arg in rpsL)
|
|
Gly34Ala (ggg/gcg)
| |
1
|
|
Pro38 (ccc/cc frameshift)
| |
1 (Lys88Arg in rpsL)
|
|
Val65Gly (gtc/ggc)
| |
1
|
|
Gly69Asp (ggt/gat)
|
1
|
2
|
|
Gly71Arg (gga/aga)
| |
1
|
|
Val88Ala (gta/gca)
| |
1
|
|
Leu91Pro (cta/cca)
| |
1
|
|
Gly92Asp (gaa/gac)
|
1
| |
|
Gly92Asp (gaa/gac); Ala205Ala (gca/gcg)
| |
3 (Lys43Arg in rpsL)
|
|
Ser100Phe (tct/ttt)
| |
1
|
|
Val110Val (gtg/gtt); Ala205Ala (gca/gcg)
|
4
| |
|
Ala138Val (gcg/gtg)
| |
2
|
|
Ala200Glu (gcg/gag) + Ala205Ala (gca/gcg)
| |
1
|
|
Ala205Ala (gca/gcg)
|
18
|
4 (3 with mutations in rpsL)
|
|
Strains phenotypically susceptible to EMB (n=)
|
Strains phenotypically resistant to EMB (n=)
|
embB
|
wild type
|
82
|
4(5)
|
|
Met306Ile (atg/ata)
| |
6
|
|
Met306Val (atg/gtg)
| |
1
|
|
Trp332Arg (tgg/cgg)
| |
1
|
|
Gln497Lys (cag/aag)(3)
| |
1
|
|
Gln1002Arg (cag/cgc)(3)
| |
2
|
|
Strains phenotypically susceptible to PZA (n=)
|
Strains phenotypically resistant to PZA (n=)
|
pncA
|
wild type
|
84
|
3
|
|
−11 (a/g)
| |
1
|
|
Ile5 (atc/atcc frameshift)
| |
1
|
|
Thr47Ala (acc/gcc)
|
2
| |
|
Tyr64 (tat/tata frameshift)
| |
1
|
|
Lys96Glu (aag/gag)
|
1
| |
|
Gln141 (cag/cag acggcgccag (insertion of 10 bp → frameshift)
| |
1
|
|
Ala146Glu (gcg/gag)
| |
1
|
|
Gly162Asp (ggt/gat)
| |
1
|
|
Leu172Pro (ctg/ccg)
| |
1
|