Gene | Mutation | Strains phenotypically susceptible to INH (n=) | Strains phenotypically resistant to INH (n=) |
---|---|---|---|
katG | wild type | 65 | 4(1) |
 | Ala291Thr (gct/act); Ser315Thr (agc/acc) |  | 1 |
 | Trp300Cys (tgg/tgc) |  | 1 |
 | Thr302Arg (acg/agg) |  | 1 |
 | Ser315Thr (acg/acc) |  | 21 |
 | Asp329 (gac/ggac frameshift) |  | 1 |
 | Arg463Leu (cgg/ctg)(2) |  | 2 |
 | Gln471Arg (cag/cgg); Ser315Thr (agc/acc) |  | 1 |
 | Strains phenotypically susceptible to RIF (n=) | Strains phenotypically resistant to RIF (n=) | |
rpoB | wild type | 76 | Â |
 | Thr481Ala (acc/gcc)(3) |  | 1 |
 | Leu511Pro (ctg/ccg)(4) | 1 |  |
 | Asp516Tyr (gac/tac)(4) | 3 |  |
 | His526Tyr (cac/tac) |  | 3 |
 | His526Arg (cac/cgc) |  | 3 |
 | Ser531Leu (tcg/ttg) |  | 8 |
 | Leu533Pro (ctg/ccg)(4) | 1 | 1 |
 | Strains phenotypically susceptible to SM (n=) | Strains phenotypically resistant to SM (n=) | |
rpsL | wild type | 56 | 21 |
 | Lys43Arg (aag/agg) |  | 11 |
 | Lys88Arg (aag/agg) | 1 | 8 |
gidB | wild type | 26 (2 with mutations in rrs/rpsL) | 15 (10 with mutations in rpsL) |
 | Leu16Arg (ctt/cgt) | 4 | 2 |
 | Leu16Arg (ctt/cgt); Gln127stop (caa/taa); Ala161Ala (gcc/gcg) | 1 |  |
 | Leu16Arg (ctt/cgt); Ala161Ala (gcc/gcg) | 2 | 1 (Lys43Arg in rpsL) |
 | Leu16Arg (ctt/cgt); Ala200Glu (gcg/gag) |  | 2 |
 | Leu16Arg (ctt/cgt); Ala205Ala (gca/gcg) |  | 1 (Lys43Arg in rpsL) |
 | Gly34Ala (ggg/gcg) |  | 1 |
 | Pro38 (ccc/cc frameshift) |  | 1 (Lys88Arg in rpsL) |
 | Val65Gly (gtc/ggc) |  | 1 |
 | Gly69Asp (ggt/gat) | 1 | 2 |
 | Gly71Arg (gga/aga) |  | 1 |
 | Val88Ala (gta/gca) |  | 1 |
 | Leu91Pro (cta/cca) |  | 1 |
 | Gly92Asp (gaa/gac) | 1 |  |
 | Gly92Asp (gaa/gac); Ala205Ala (gca/gcg) |  | 3 (Lys43Arg in rpsL) |
 | Ser100Phe (tct/ttt) |  | 1 |
 | Val110Val (gtg/gtt); Ala205Ala (gca/gcg) | 4 |  |
 | Ala138Val (gcg/gtg) |  | 2 |
 | Ala200Glu (gcg/gag) + Ala205Ala (gca/gcg) |  | 1 |
 | Ala205Ala (gca/gcg) | 18 | 4 (3 with mutations in rpsL) |
 | Strains phenotypically susceptible to EMB (n=) | Strains phenotypically resistant to EMB (n=) | |
embB | wild type | 82 | 4(5) |
 | Met306Ile (atg/ata) |  | 6 |
 | Met306Val (atg/gtg) |  | 1 |
 | Trp332Arg (tgg/cgg) |  | 1 |
 | Gln497Lys (cag/aag)(3) |  | 1 |
 | Gln1002Arg (cag/cgc)(3) |  | 2 |
 | Strains phenotypically susceptible to PZA (n=) | Strains phenotypically resistant to PZA (n=) | |
pncA | wild type | 84 | 3 |
 | −11 (a/g) |  | 1 |
 | Ile5 (atc/atcc frameshift) |  | 1 |
 | Thr47Ala (acc/gcc) | 2 |  |
 | Tyr64 (tat/tata frameshift) |  | 1 |
 | Lys96Glu (aag/gag) | 1 |  |
 | Gln141 (cag/cag acggcgccag (insertion of 10 bp → frameshift) |  | 1 |
 | Ala146Glu (gcg/gag) |  | 1 |
 | Gly162Asp (ggt/gat) |  | 1 |
 | Leu172Pro (ctg/ccg) |  | 1 |