Table 3 Cluster profiling: KEGG cellular pathways and Gene Ontology
Temporal profile over 24 h | Cellular Pathway | Impact Factor | GO number | GO name |
|---|---|---|---|---|
| MAPK signaling pathway | 7.3 | GO:0006916 | anti-apoptosis |
| Â | Apoptosis | 7.1 | GO:0045063 | T-helper 1 cell differentiation |
| Â | Â | Â | GO:0031665 | negative regulation of LPS-mediated signaling pathway |
| Â | Â | Â | GO:0014912 | negative regulation of smooth muscle cell migration |
| Â | Â | Â | GO:0043405 | regulation of MAP kinase activity |
| Epithelial cell signaling in H. pylori infection | 12.4 | GO:0006935 | chemotaxis |
| Â | Cytokine-cytokine receptor interaction | 10.2 | GO:0006954 | inflammatory response |
| Â | Bladder cancer | 6.8 | GO:0006955 | immune response |
| Â | Toll-like receptor signaling pathway | 5.9 | GO:0045091 | regulation of retroviral genome replication |
| Â | Pathways in cancer | 4.8 | GO:0042119 | neutrophil activation |
| Â | Â | Â | GO:0050930 | induction of positive chemotaxis |
| Â | Â | Â | GO:0030593 | neutrophil chemotaxis |
| Â | Â | Â | GO:0030155 | regulation of cell adhesion |
| Â | Â | Â | GO:0019722 | calcium-mediated signaling |
| Circadian rhythm | 20.0 | GO:0006915 | apoptosis |
| Â | MAPK signaling pathway | 10.7 | GO:0006950 | response to stress |
| Â | mTOR signaling pathway | 7.5 | GO:0007050 | cell cycle arrest |
| Â | Tight junction | 7.0 | GO:0030216 | keratinocyte differentiation |
| Â | Jak-STAT signaling pathway | 6.7 | GO:0006865 | amino acid transport |
| Â | Cytokine-cytokine receptor interaction | 6.5 | GO:0031424 | keratinization |
| Â | Regulation of autophagy | 6.4 | GO:0008652 | amino acid biosynthetic process |
| Â | p53 signaling pathway | 5.6 | GO:0006220 | pyrimidine nucleotide metabolic process |
| Â | Regulation of actin cytoskeleton | 5.2 | Â | Â |
| Â | TGF-beta signaling pathway | 5.2 | Â | Â |
| Â | Natural killer cell mediated cytotoxicity | 4.7 | Â | Â |
| Melanogenesis | 8.3 | GO:0030146 | diuresis |
| Â | GnRH signaling pathway | 7.6 | GO:0030147 | natriuresis |
| Â | ErbB signaling pathway | 6.7 | GO:0048661 | positive regulation of smooth muscle cell proliferation |
| Â | Pathways in cancer | 6.4 | GO:0002268 | follicular dendritic cell differentiation |
| Â | Epithelial cell signaling in H. pylori infection | 5.7 | GO:0031583 | activation of phospholipase D activity by G-protein coupled receptor protein signaling |
| Â | Â | Â | GO:0014826 | vein smooth muscle contraction |
| Â | Â | Â | GO:0002467 | germinal center formation |
| Â | Â | Â | GO:0030578 | PML body organization |
| Â | Â | Â | GO:0030195 | negative regulation of blood coagulation |
| Â | Â | Â | GO:0043507 | positive regulation of JUN kinase activity |
| Antigen processing and presentation | 13.7 | GO:0006695 | cholesterol biosynthetic process |
| Â | MAPK signaling pathway | 9.7 | GO:0006986 | response to unfolded protein |
| Â | Bladder cancer | 6.2 | GO:0006916 | anti-apoptosis |
| Â | Pathways in cancer | 6.1 | GO:0006139 | nucleobase, -side, -tide and nucleic acid metabolic process |
| Â | Regulation of actin cytoskeleton | 6.1 | GO:0008299 | isoprenoid biosynthetic process |
| Â | Â | Â | GO:0006601 | creatine biosynthetic process |
| Â | Â | Â | GO:0009416 | response to light stimulus |
| Â | Â | Â | GO:0043154 | negative regulation of caspase activity |
| Â | Â | Â | GO:0007566 | embryo implantation |
