H. pylori clinical isolates have diverse babAB genotype distributions over different topographic sites of stomach with correlation to clinical disease outcomes

Table 4 The number of CT repeats in the 5’ coding region of babB at locus B

Case No.	Antrum isolates (n = 2) (CT repeat number)	Corpus isolates (n = 2) (CT repeat number)	Concordance	Change of CT repeat in the corpus
2	8, 8	8, 8	+	-
12	8, 8	8, 8	+	-
24	7, 7	7, 7	+	-
30	11, 11	11, 11	+	-
1	8, 8	7, 10	-	+
11	8, 8	7, 9	-	+
26	8, 8	8, 9	-	+
6	9, 9	9, 12	-	+
21	7, 7	9, 10	-	+
27	9, 9	9, 8	-	+
14	8, 8	7, 7	-	-
17	7, 10	8, 7	-	+

Four patients (no. 2, 12, 24, 30) were infected by isolates with one kind of CT repeat (7, 8 and 11) across the antrum and corpus, but only one of them (no. 24) had an out of frame babB. In the other patients (no. 1, 11 and 26), their antrum isolates contained 8 CT repeats but the corpus isolates changed to 7, 9 or 10 repeats. For the patients (no. 6, 21 and 27) who were infected by the antrum isolates with 7 or 9 CT repeats, their corpus isolates also had a change of CT repeats, but the number of CT repeats was still out of frame (9, 10 and 12), except in one isolate from patient no. 27 (CT repeats = 8).

ISSN: 1471-2180