Mice on simvastatin prophylaxis show enhanced protection from bacteremia. Bacterial titers in the blood of challenged mice 24, 36 and 42 h after infection. Mice on Control (n = 11), Low (n = 11) or High (n = 12) diet were challenged intratracheally with 1 X 105 cfu. Mice receiving statins had significantly fewer bacteria in the blood. Data are presented as the mean ± SEM. Statistics were determined by a two-tailed student’s t-test. P < 0.05 was considered significant.