Simvastatin prophylaxis decreases bacterial burdens in the lungs. Bacterial titers in the lungs 24 and 42 h after infection of mice fed the Control, Low or High statin diet and challenged intratracheally with 1 X 105 cfu. Each circle represents an individual mouse. Horizontal lines indicate the median; dashed lines indicate limit of detection Mice receiving statins had significantly lower bacterial titers in the lungs 42 h after infection. Data are presented as the mean ± SEM. Statistics were determined by a two-tailed student’s t-test. P < 0.05 was considered significant on comparison to Control fed mice.