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Figure 1 | BMC Microbiology

Figure 1

From: Procalcitonin neutralizes bacterial LPS and reduces LPS-induced cytokine release in human peripheral blood mononuclear cells

Figure 1

Neutralization by PCT of LPS from S. typhimurium and E. coli . The effect of PCT on S. typhimurium and E. coli LPS (100 pg/ml) reactivity was evaluated as O. D. (405 nm) by the chromogenic LAL test after 30 minutes incubation of the above reported LPS concentration: with 0 pg/ml PCT (LPS 30 min), with 5000 pg/ml PCT (LPS + PCT 5000 30 min), 500 pg/ml PCT (LPS + PCT 500 30 min). Results are presented as means ± SEM of at least four experiments each carried out in duplicate. Statistical significance between groups was assessed by Student’s t test. A p < 0.05 was considered significant, whereas not significant (n.s.) difference was associated with a p ≥ 0.05. Statistics were performed in comparison with respective LPS type-stimulated PCT-untreated cells (LPS 30 min), and the exact significance index is indicated on the top of the horizontal line encompassing the two statistically compared bars.

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