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Table 1 Gene expression differences of C. glutamicum WT in response to biotin limitation, biotin excess or supplementation with dethiobiotin

From: Characterization of the biotin uptake system encoded by the biotin-inducible bioYMN operon of Corynebacterium glutamicum

Genea Annotationa Relative mRNA level
   1 μg/l biotin 20000 μg/l biotin dethiobiotin b
   200 μg/l biotin 200 μg/l biotin biotinb
cg0095 biotin synthase BioB 6.8 0.1 11.3
cg0096 hypothetical protein 5.5 0.2 3.6
cg0097 hypothetical protein 10.1 0.1 3.5
cg0126 hypothetical protein 0.5 n.d. 2.1
cg0486 ABC-type transporter. permease component n.d. 0.5 n.d.
cg0634 ribosomal protein L15 RplO 0.4 n.d. n.d.
cg1141 lactam utilization protein n.d. 0.5 1.2
cg1142 transport system 2.1 0.4 1.2
cg1214 cysteine desulfhydrase/selenocysteine lyase NadS 1.9 0.5 1.3
cg1216 quinolate synthase A NadA 1.9 0.5 1.4
cg1218 ADP-ribose pyrophosphatase NdnR 2.1 0.4 2.0
cg1671 hypothetical protein n.d. 2.0 0.3
cg2147 Biotin transport protein BioY 18.8 0.1 4.4
cg2148 Biotin transport protein BioM 4.9 0.2 2.6
cg2149 Biotin transport protein BioN 2.0 0.4 1.6
cg2320 predicted transcriptional regulator MarR family 2.0 0.5 1.6
cg2560 isocitrate lyase AceA 3.1 0.4 1.0
cg2747 metalloendopeptidases-like protein n.d. 0.4 2.3
cg2883 SAM-dependent methyltransferase 2.2 0.2 n.d.
cg2884 putative dipeptide/tripeptide permease 8.9 0.1 5.6
cg2885 adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 3.8 0.1 n.d.
cg3231 hypothetical protein 0.5 n.d. n.d.
cg3289 thiol:disulfide interchange protein TlpA 0.4 n.d. n.d.
  1. aGene numbers and annotations of the revised C. glutamicum genome published by NCBI as NC003450
  2. bRatio of the mRNA level in cells grown in CGXII with 200 μg/l dethiobiotin to that of cells grown with 200 μg/l biotin