Role of downstream components of the innate immunity pathways on intestinal bacterial proliferation and C. elegans lifespan. Survival of C. elegans mutants with defective expression of antimicrobial peptides (Panel A) or oxidative stress enzymes (Panel C) when grown on lawns of E. coli OP50. Panel B: Intestinal load of E. coli OP50 (dark bars) or S. typhimurium SL1344 (grey bars) with altered intestinal expression of antimicrobial peptides or oxidative stress enzymes (Panel D) on day 2 (L4 stage + 2 days) of their lifespan. Data represent Mean ± SD from experiments involving 30 worms/group. Significant (p < 0.05) differences in proliferation either E. coli or Salmonella compared to N2 worms indicated by *.