Skip to main content

Table 2 Results of rifampicin susceptibility testing and rpoB genotyping

From: Genetic basis of rifampicin resistance in methicillin-resistant Staphylococcus aureus suggests clonal expansion in hospitals in Cape Town, South Africa

Clonal type1 (clonal complex)

PFGE cluster2 (n)/spa type (n)

Isolate origin (isolate name)

Rifampicin MIC (mg/L)3

Amino acid position4

Nucleotide substitution

Amino acid substitution

ST22- MRSA-IV (22)

Sporadic isolate (1)/t032 (1)

Cape Town, RSA5

≤ 0.016

498

GCG → GCT

-

    

554

CAT → CAC

-

    

599

AAT → AAC

-

ST36- MRSA-II (30)

F (1)/t021 (1)

Cape Town, RSA

≤ 0.016

474

AAC → AAT

-

    

498

GCG → GCT

-

    

502

GTA → GTG

-

    

518

ACA → ACG

-

ST5- MRSA-I (5)

C (1)/t045 (1)

Cape Town, RSA

≥ 256

481

C AT → T AT

H481Y

    

498

GCG → GCT

-

    

630

AAT → AAC

-

    

658

GGT → GGA

-

ST612- MRSA-IV (8)

D (2), E (5), sporadic isolates (2)/t064 (3), t1443 (5), t1257 (1)

Cape Town, RSA

≥ 256

481

C AT → A AT

H481N

    

498

GCG → GCT

-

    

512

CGT → CGC

-

    

527

ATT → ATG

I527M

ST612- MRSA-IV (8)

ND6 (2)/t064 (2)

RSA (N83; N84)

≥ 256

481

C AT → A AT

H481N

    

498

GCG → GCT

-

    

512

CGT → CGC

-

    

527

ATT → ATG

I527M

ST612- MRSA-IV (8)

ND (1)/t064 (1)

Australia (04-17052)

≥ 256

481

C AT → A AT

H481N

    

498

GCG → GCT

-

    

512

CGT → CGC

-

    

527

ATT → ATG

I527M

ST612- MRSA-IV (8)

ND (1)/t7571 (1)

Australia (09-15534)

≥ 256

481

C AT → A AT

H481N

    

498

GCG → GCT

-

    

512

CGT → CGC

-

    

527

ATT→ATG

I527M

    

579

AA A→AG A

K579R

  1. 1 Clonal types are indicated using the current international nomenclature (sequence type (ST) - antimicrobial phenotype - staphylococcal cassette chromosome mec (SCCmec) type)
  2. 2 PFGE, pulsed-field gel electrophoresis
  3. 3 As determined by E-test
  4. 4 S. aureus co-ordinates
  5. 5 RSA, Republic of South Africa
  6. 6 ND, not determined