Deletion mutations and antiviral treatments. The profiles of different types of HBV deletions between patients with (+) and without (−) antiviral therapy based on 51 HBV full-length sequences. Upper panel: analysis from all samples of CC, CH, LC, and HCC. Lower panel: analysis without patients of progressive liver diseases. Antiviral medication was grouped as nucleotide analog only (left), IFN only (middle), and either one or both (right). Each deletion and the ratio of wt virus to mutants were labeled under the histogram.