The protein interaction network of a taxis signal transduction system in a Halophilic Archaeon

BMC Microbiology

Table 1 Functions of the Che proteins of Hbt.salinarum

Protein	Demonstrated functions in Hbt.salinarum	Demonstrated functions of holomogues in other organisms
CheA	Phosphorylation of CheY [16]	Phosphorylation of CheY and CheB [17, 18]
CheW1		Coupling of CheA to receptors [19]
CheW2		Coupling of CheA to receptors [19]
CheY	Essential for switching and	Switching/CCW (CW) rotation in Bsu (Eco) [20–22]
	CCW swimming [7]
CheB	Receptor demethylation and	Receptor demethylation [23, 24]; in Eco also
	deamidation [25]	deamidation [26]
CheR	Receptor methylation [25]	Receptor methylation [23, 27]
CheC1		CheY-P phosphatase [28], CheD inhibition [29, 30]
CheC2		CheY-P phosphatase [28], CheD inhibition [29, 30]
CheC3		CheY-P phosphatase [28], CheD inhibition [29, 30]
CheD		Receptor deamidase and enhancer of CheC in Bsu
		[30, 31], receptor deamidase and methylesterase in
		Tma [32]
CheF1	Coupling Che system to
	archaeal flagellum [10]
CheF2

Functions in other organisms are thought to be universal, unless certain organisms are indicated (Eco: E.coli, Bsu: B.subtilis, Tma: T.maritima).

ISSN: 1471-2180