TY - JOUR AU - Moreira, Ricardo N. AU - Domingues, Susana AU - Viegas, Sandra C. AU - Amblar, Mónica AU - Arraiano, Cecília M. PY - 2012 DA - 2012/11/20 TI - Synergies between RNA degradation and trans-translation in Streptococcus pneumoniae: cross regulation and co-transcription of RNase R and SmpB JO - BMC Microbiology SP - 268 VL - 12 IS - 1 AB - Ribonuclease R (RNase R) is an exoribonuclease that recognizes and degrades a wide range of RNA molecules. It is a stress-induced protein shown to be important for the establishment of virulence in several pathogenic bacteria. RNase R has also been implicated in the trans-translation process. Transfer-messenger RNA (tmRNA/SsrA RNA) and SmpB are the main effectors of trans-translation, an RNA and protein quality control system that resolves challenges associated with stalled ribosomes on non-stop mRNAs. Trans-translation has also been associated with deficiencies in stress-response mechanisms and pathogenicity. SN - 1471-2180 UR - https://doi.org/10.1186/1471-2180-12-268 DO - 10.1186/1471-2180-12-268 ID - Moreira2012 ER -