TY - JOUR AU - Stone, Joshua K. AU - Mayo, Mark AU - Grasso, Stephanie A. AU - Ginther, Jennifer L. AU - Warrington, Stephanie D. AU - Allender, Christopher J. AU - Doyle, Adina AU - Georgia, Shalamar AU - Kaestli, Mirjam AU - Broomall, Stacey M. AU - Karavis, Mark A. AU - Insalaco, Joseph M. AU - Hubbard, Kyle S. AU - McNew, Lauren A. AU - Gibbons, Henry S. AU - Currie, Bart J. AU - Keim, Paul AU - Tuanyok, Apichai PY - 2012 DA - 2012/11/05 TI - Detection of Burkholderia pseudomallei O-antigen serotypes in near-neighbor species JO - BMC Microbiology SP - 250 VL - 12 IS - 1 AB - Burkholderia pseudomallei is the etiological agent of melioidosis and a CDC category B select agent with no available effective vaccine. Previous immunizations in mice have utilized the lipopolysaccharide (LPS) as a potential vaccine target because it is known as one of the most important antigenic epitopes in B. pseudomallei. Complicating this strategy are the four different B. pseudomallei LPS O-antigen types: A, B, B2, and rough. Sero-crossreactivity is common among O-antigens of Burkholderia species. Here, we identified the presence of multiple B. pseudomallei O-antigen types and sero-crossreactivity in its near-neighbor species. SN - 1471-2180 UR - https://doi.org/10.1186/1471-2180-12-250 DO - 10.1186/1471-2180-12-250 ID - Stone2012 ER -