Table 1 The characteristics of the rifampicin-resistant S. aureus isolates studied
MRSA rpoB mutations | Number of isolates | Mutation frequency % | Rifampicin MIC | Resistance pattern | ||
|---|---|---|---|---|---|---|
Nucleotide mutation | Amino acid substitution | MIC(mg/L) | Number of isolates | |||
TCA/TTA | 486Leu/Ser | 4 | 4.5% | 4 | 4 | CIP+E+GEN+TET(3) |
CIP+E+GEN+TET+CC (1) | ||||||
CAT/AAT | 481His/Asn | 1 | 1.1% | 4 | 1 | CIP+E+GEN+TET(1) |
CAT/AAT+TTA/TCA | 481His/Asn+466Leu/Ser | 45 | 87.5% | 32 | 45 | CIP+E+GEN+TET(7) |
CIP+E+GEN+TET+CC (35) | ||||||
CIP+E+GEN+TET+CC+SXT(2) | ||||||
CIP+E+GEN+TET+CC+SXT+QD(1) | ||||||
CAT/AAT+TTA/TCA | 481His/Asn+466Leu/Ser | 14 | 64 | 14 | CIP+E+GEN+TET+CC (12) | |
CIP+E+GEN+TET+CC +SXT(2) | ||||||
CAT/AAT+TTA/TCA | 481His/Asn+466Leu/Ser | 11 | 128 | 11 | CIP+E+GEN+TET+CC (8) | |
CIP+E+GEN+TET+CC +SXT(3) | ||||||
CAT/AAT+TTA/TCA | 481His/Asn+466Leu/Ser | 7 | 256 | 7 | CIP+E+GEN+TET+CC +SXT(7) | |
CAT/AAT+GCT/GAT | 481His/Asn+477Ala/Asp | 5 | 5.7% | 64 | 5 | CIP+E+GEN+TET+CC (5) |
CAT/AAT+TTA/TCA+GCT/GAT | 481His/Asn+466Leu/Ser+477Ala/Asp | 1 | 1.1% | 128 | 1 | CIP+E+GEN+TET+CC (1) |